恶性肿瘤合并心房颤动患者血栓栓塞发生的影响因素  

Risk Factors of Thromboembolism in Patients of Malignant Tumor withAtrial Fibrillation

作　　者：杨明栋[1] 翟晓江[1] 毕旋律 YANG Mingdong;ZHAI Xiaojiang;BI Xuanlv(Nanyang Oilfield General Hospital,Nanyang,473132)

机构地区：[1]河南省南阳油田总医院,473132

出　　处：《实用癌症杂志》2021年第7期1194-1197,共4页The Practical Journal of Cancer

摘　　要：目的探讨恶性肿瘤心房颤动患者发生血栓栓塞的影响因素。方法以肿瘤科治疗的122例恶性肿瘤合并发心房颤动并发生血栓栓塞的患者为血栓栓塞组,按照1∶1比例随机选取同期未发生血栓栓塞的122例恶性肿瘤并发心房颤动患者为对照组,自行设计调查问卷对可能引起血栓栓塞的影响因素进行调查,并分析结果。结果2组患者性别、高血压及糖尿病、肿瘤分期及分化程度的分布之间比较差异无统计学意义(P>0.05)。血栓栓塞组患者合并冠心病、实体瘤、行经外周静脉穿刺中心静脉置管(PCⅡ)、合并感染、对血栓栓塞有预防措施等的占比分别为49.18%、75.41%、29.51%、31.15%、31.15%,对照组分别为36.25%、60.66%、18.03%、19.67%、50.82%,比较差异有统计学意义(P<0.05);多因素条件Logistic回归分析结果显示合并冠心病、实体瘤、行PCⅡ、合并感染是引起血栓栓塞发生的独立危险因素(P<0.05),血栓栓塞预防措施是保护性因素(P<0.05)。结论合并冠心病、实体瘤、行PCⅡ、合并感染是恶性肿瘤合并心房颤动患者发生血栓栓塞的主要影响因素,采取血栓栓塞的预防有助于降低患者血栓栓塞发生的风险。Objective To discuss risk factors of thromboembolism in patients of malignant tumor with atrial fibrillation.Methods 122 patients with malignant tumor with atrial fibrillation and thromboembolism as the thromboembolism group,according to 1:1 ratio,122 patients of malignant tumor with atrial fibrillation who did not develop thromboembolism during the same period as the control group,we designed the questionnaire and investigated the factors that may cause thromboembolism,and analysis result.Results There were no statistically significant differences between the 2 groups in gender,hypertension,diabetes mellitus,tumor stage and degree of differentiation(P>0.05).The coronary heart disease,solid tumor,peripheral venipuncture central venous catheterization(PICC),concurrent infection and the prevention rates of thromboembolism were 49.18%,75.41%,29.51%,31.15% and 31.15% in the thromboembolism group,36.25%,60.00%,18.03%,19.67% and 50.82% in the control group,the difference was statistically significant(P<0.05).Multivariate logistic regression analysis showed that coronary heart disease,solid tumor,PCII and concurrent infection were independent risk factors for thromboembolism(P<0.05),thromboembolic prophylaxis was a protective factor(P<0.05).Conclusion The coronary heart disease,solid tumor,PCII,concurrent infection is the main influencing factor of thromboembolism in patients of malignant tumor with atrial fibrillation,prevention of thromboembolism is helpful to reduce the risk of thromboembolism.

关 键 词：恶性肿瘤 心房颤动 血栓栓塞 影响因素 

分 类 号：R730.6[医药卫生—肿瘤]