Giant androgen-producing adrenocortical carcinoma with atrial flutter: A case report and review of the literature  

作　　者：Mircea-Florin Costache Raluca-Elena Arhirii Simona-Juliette Mogos Corina Lupascu-Ursulescu Cezara-Ioana Litcanu Adi-Ionut Ciumanghel Catalina Cucu Cristina-Mihaela Ghiciuc Antoniu-Octavian Petris Nicolae Danila 

机构地区：[1]Surgery Clinic,Saint Spiridon University Clinical Emergency Hospital,Iasi 700111,Romania [2]Cardiology Clinic,Saint Spiridon University Clinical Emergency Hospital,Iasi 700111,Romania [3]Department of Endocrinology,Faculty of Medicine,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania [4]Endocrinology Clinic,Saint Spiridon University Clinical Emergency Hospital,Iasi 700111,Romania [5]Department of Radiology and Imaging Sciences,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania [6]Radiology Clinic,Saint Spiridon University Clinical Emergency Hospital,Iasi 700111,Romania [7]Radiotherapy Clinic,Regional Institute of Oncology,Iasi 700483,Romania [8]Anesthesia and Intensive Care Department,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania [9]Anesthesia and Intensive Care Department,Saint Spiridon University Clinical Emergency Hospital,Iasi 700111,Romania [10]Histopatology Department,Saint Spiridon University Clinical Emergency Hospital,Iasi 700111,Romania [11]Department of Pharmacology,Clinical Pharmacology and Algesiology,Faculty of Medicine,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania [12]Department of Cardiology,Faculty of Medicine,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania [13]Surgery Clinic,Faculty of Medicine,Grigore T.Popa University of Medicine and Pharmacy,Iasi 700115,Romania

出　　处：《World Journal of Clinical Cases》2021年第20期5575-5587,共13页世界临床病例杂志

摘　　要：BACKGROUND Adrenocortical carcinoma(ACC),the second most aggressive malignant tumor,lacks epidemiological data worldwide;therefore,every new case can improve the understanding of the pathology and treatment of this malignancy.CASE SUMMARY We present the case of a 66-year-old Caucasian woman with a giant androgenproducing ACC(21 cm×17 cm×12 cm;2100 g),without metastases,which unusually presented with an acute onset of atrial flutter and congestive heart failure.The cardiac complications observed in our case support the hypothesis that androgen excess in women is a cardiovascular risk factor.Androgen excess in women can be a rare cause of reversible dilated cardiomyopathy,therefore a comprehensive approach to the patient is essential to improve the recognition of androgen-secreting ACC.The atrial flutter was remitted after initiation of drug treatment during admission.The severe heart failure was totally remitted at 6 mo after radical open surgery to remove the giant ACC.CONCLUSION Radical open surgery to remove a giant androgen-producing ACC was the firstline treatment to cure the excess of androgen,which determined the total remission of cardiac complications at 6 mo after surgery in the women of this case report.

关 键 词：Adrenocortical carcinoma ADRENALECTOMY Androgen secreting tumor Heart failure Atrial flutter Case report 

分 类 号：R736.6[医药卫生—肿瘤]