^(99)Tcm-3PRGD_(2)SPECT/CT分子影像在乳腺癌诊疗中的应用进展  

Progress of^(99)Tcm-3PRGD_(2)SPECT/CT molecular imaging in the diagnosis and treatment of breast cancer

作　　者：康菁芬 刘海燕[1] 李彩红 师志勇 Kang Jingfen;Liu Haiyan;Li Caihong;Shi Zhiyong(Department of Nuclear Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院核医学科,太原030001

出　　处：《国际放射医学核医学杂志》2021年第4期251-256,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：山西省留学回国人员科技活动择优资助项目(2019-5);山西省新兴产业领军人才项目(3);山西省研究生教育创新项目(2020SY247)。

摘　　要：乳腺癌是女性发病率最高的恶性肿瘤。99Tcm-联胼尼克酰胺-3聚乙二醇-精氨酸-甘氨酸-天冬氨酸环肽二聚体(^(99)Tcm-3PRGD_(2))是近年来人工合成的可用于乳腺癌分子显像的一种SPECT示踪剂。^(99)Tcm-3PRGD_(2)SPECT/CT可用于早期诊断乳腺癌并进行准确的分期及分子分型,据此进行诊疗方案的选择,有助于降低患者的病死率,并提高患者的生活质量。笔者就^(99)Tcm-3PRGD_(2)SPECT/CT在乳腺癌诊疗过程中的应用进展进行综述,并作出展望。Breast cancer is the most common malignant tumor in women.99Tcm-hydrazinonicotinamide(HYNIC)-(poly-(ethylene glycol),PEG)4-Glu(cyclo(Arg-Gly-Asp-D-Phe-Lys(PEG4)))2(^(99)Tcm-3PRGD_(2))is a kind of artificial synthesized molecular tracer,which can be used to SPECT/CT for breast cancer imaging.^(99)Tcm-3PRGD_(2)SPECT/CT can be used for early diagnosis,accurate staging and molecular typing of the breast cancer.Selecting the treatment regimen according to the result of^(99)Tcm-3PRGD_(2)SPECT/CT is helpful to reduce the mortality of patients and improve the quality of life of patients.The application progress of^(99)Tcm-3PRGD_(2)SPECT/CT in the diagnosis of breast cancer is reviewed and prospected in this paper.

关 键 词：乳腺肿瘤 体层摄影术 发射型计算机 单光子 整合素ΑVΒ3 体层摄影术 X线计算机 RGD序列 

分 类 号：R737.9[医药卫生—肿瘤] R730.44[医药卫生—临床医学]