Neolignans from Selaginella moellendorffii  

作　　者：Jing-Xian Zhuo Yue-Hu Wang Xing-Li Su Ren-Qiang Mei Jun Yang Yi Kong Chun-Lin Long 

机构地区：[1]Key Laboratory of Economic Plants and Biotechnology,and Yunnan Key Laboratory for Wild Plant Resources,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]School of Life Science&Technology,China Pharmaceutical University,Nanjing 210009,China [3]College of Life and Environmental Sciences,Minzu University of China,Beijing 100081,China

出　　处：《Natural Products and Bioprospecting》2016年第3期161-166,共6页应用天然产物（英文）

基　　金：This work was funded by the Ministry of Science&Technology of China(2012FY110300);the National Natural Science Foundation of China(3116140345);the Minzu University of China(YLDX01013,2015MDTD16C).

摘　　要：Two new neolignans selaginellol(1)and selaginellol 4'-O-β-D-glucopyranoside(2),together with seven known compounds(3–9),were isolated from the whole plant of Selaginella moellendorffii.The structures of the new isolates were determined through spectroscopic data analysis.Compounds 1–9,as well as compounds 10–18 previously isolated from the species,were measured for the activity against platelet aggregation induced by ADP or collagen.Three neoligans(8,11,and 12),one flavanone(14),and one alkaloid(16)showed inhibitory activity against ADP-or collagen-induced platelet aggregation as compared with tirofiban.The dihydrobenzofuran neolignans(8,11,and 12)are more potent than the benzofuran neolignan(13)and other types of neolignans(1–7).Glucosidation of the dihydrobenzofuran neolignans(11 and 12)is helpful for the activity.Graphical Abstract Two new neolignans selaginellol(1)and selaginellol 40-O-b-D-glucopyranoside(2)were isolated from the whole plant of Selaginella moellendorffii.Several compounds from this plant showed the activity against platelet aggregation induced by ADP or collagen.

关 键 词：SELAGINELLACEAE Selaginella moellendorffii Lignans ANTIPLATELET 

分 类 号：O62[理学—有机化学]