血清几丁质酶1、鸢尾素表达与不同类型糖尿病视网膜病变患者微血管损伤的相关性  

Correlation between the expression of serum chitotriosidase and Irisin and microvascular injury in patients with different types of diabetic retinopathy

作　　者：丁红萍 季晓燕[1] 黄江[1] 陈之阳 DING Hongping;JI Xiaoyan;HUANG Jiang;CHEN Zhiyang(Department of Ophthalmology,the Second Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu Province,China)

机构地区：[1]苏州大学附属第二医院眼科,江苏省苏州市215000

出　　处：《眼科新进展》2021年第7期664-667,共4页Recent Advances in Ophthalmology

摘　　要：目的研究血清几丁质酶1(CHIT1)、鸢尾素(Irisin)的表达与不同类型糖尿病视网膜病变(DR)患者微血管损伤的相关性。方法选取我院2018年6月至2020年6月收治的106例糖尿病患者,根据不同疾病类型分为A组(增生型DR)、B组(非增生型DR)、C组(无视网膜病变)。检测各组患者血清CHIT1、Irisin水平以及外周血循环内皮细胞(CEC)、内皮祖细胞(EPC)、循环祖细胞(CPC)比例并进行比较,采用Pearson相关性分析DR患者血清CHIT1、Irisin的水平与CEC、EPC、CPC比例的相关性。Logistic回归分析影响增生型DR发生的危险因素。结果A组、B组、C组患者血清CHIT1、Irisin水平以及外周血CEC、EPC、CPC比例差异均有统计学意义(均为P<0.001),其中A组患者血清CHIT1水平、CEC比例均明显高于B组、C组,而血清Irisin水平、EPC和CPC比例明显均低于B组、C组,差异均有统计学意义(均为P<0.05)。Pearson相关性分析结果显示,DR患者血清CHIT1水平与CEC比例均呈正相关,与EPC和CPC比例均呈负相关,而DR患者血清Irisin水平与CEC比例均呈负相关,与EPC和CPC比例均呈正相关(均为P<0.001)。增生型DR患者的糖尿病病程、血清CHIT1水平、尿微量白蛋白均明显高于其他患者,增生型DR患者的血清Irisin水平均明显低于其他患者,差异均有统计学意义(均为P<0.05)。Logistic回归分析显示,糖尿病病程、CHIT1水平、Irisin水平、尿微量白蛋白均是糖尿病患者发生增生型DR的影响因素(均为P<0.05)。结论DR患者血清CHIT1、Irisin异常表达,且与微血管损伤密切关联,是DR进展至增生型DR的影响因素。Objective To study the correlation between the expression of serum chitotriosidase(CHIT1)and irisin(Irisin)and microvascular damage in patients with different types of diabetic retinopathy(DR).Methods We selected 106 diabetic patients who admitted to our hospital from June 2018 to June 2020 and divided into group A(proliferative DR),group B(non-proliferative DR),and group C(no retinopathy)according to the type of disease.The levels of serum CHIT1 and Irisin and the proportions of peripheral blood endothelial cells(CEC),endothelial progenitor cells(EPC)and circulating progenitor cells(CPC)were detected,and the differences of indexes among the groups were compared.The correlation between the expression of serum CHIT1 and Irisin and CEC,EPC and CPC was analyzed by Pearson correlation.Logistic regression analysis was used to analyze the risk factors for proliferative DR in diabetic patients.Results The serum levels of CHIT1,Irisin and the proportion of CEC,EPC,CPC in peripheral blood cells were significantly different among the group A,group B and group C(all P<0.001).The serum levels of CHIT1 and the proportion of CEC in group A were significantly higher than those in group B and group C,while the levels of Irisin,the proportion of EPC and CPC in group A were significantly lower than those in group B and group C(all P<0.05).Pearson correlation analysis showed that the serum CHIT1 level was positively correlated with the ratio of CEC,but negatively correlated with EPC and CPC;the serum Irisin level was negatively correlated with the ratio of CEC but positively correlated with EPC and CPC(all P<0.001).The course of diabetes,serum CHIT1 and urinary microalbumin of patients with proliferative DR were significantly higher than those of patients with non-proliferative DR and no retinopathy,and the level of serum Irisin was significantly lower than that of patients with non-proliferative DR and no retinopathy(all P<0.05).Logistic regression analysis showed that duration of diabetes mellitus,CHIT1,Irisin and microalbuminuri

关 键 词：糖尿病视网膜病变 几丁质酶1 鸢尾素 微血管损伤 

分 类 号：R774.1[医药卫生—眼科]