Synthesis of L-Ascorbic Acid Lactone Derivatives  

作　　者：Li-Dong Shao Ya-Nan Wu Jun Xu Juan He Yu Zhao Li-Yan Peng Yan Li Yu-Rong Yang Cheng-Feng Xia Qin-Shi Zhao 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]Graduate School of the Chinese Academy of Sciences,University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Natural Products and Bioprospecting》2014年第3期181-188,共8页应用天然产物（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.U0932602);the National Basic Research Program of China(973 Program No.2011CB915503).

摘　　要：A small focused library which comprised of L-AA lactone derivatives was built with a facile method.This reported method was optimized by modifying the acidity of the solvent.As a result,12 L-AA lactones were synthesized.Among these lactones,lactones 8–12 were new compounds.The cytotoxicity of these synthetic compounds were investigated.

关 键 词：L-Ascorbic acid lactone CYTOTOXICITY Focused library 

分 类 号：O62[理学—有机化学]