Four New Limonoids from the Barks of Toona ciliata  

作　　者：Pan-Pan Zhang Yun-Ge Bu Shang Xue Zhi-Rong Cui Peng-Fei Tang Jun Luo Ling-Yi Kong 

机构地区：[1]State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2021年第1期81-86,共6页应用天然产物（英文）

基　　金：supports for this study were from the National Natural Science Foundation of China(31470416);the National New Drug Innovation Major Project(2018ZX09711-001-007);the National Key R&D Program of China(2018YFC1707105);the"Double First-Class"University project(CPU2018GY08,China).

摘　　要：Four new limonoids,toonayunnanaes F−I(1−4),and six known compounds(5−10)were isolated from the barks of Toona ciliata.Their structures were elucidated by thoroughly analyzing of NMR and HRMS data,and single-crystal X-ray diffraction of 1.The oxetane ring moiety in 1 was rare in limonoids and other natural products.Compound 1 showed nitric oxide(NO)inhibitory effect with an IC5038.45±0.41μM in lipopolysaccharide(LPS)-activated RAW 264.7 macrophages.

关 键 词：MELIACEAE Toona ciliate LIMONOIDS NO inhibitory effects 

分 类 号：O62[理学—有机化学]