Structures,Chemical Conversions,and Cytotoxicity of Tricholopardins C and D,Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum  

作　　者：Chen Shi Yue‑Ling Peng Juan He Zheng‑Hui Li Ji‑Kai Liu Tao Feng 

机构地区：[1]School of Pharmaceutical Sciences,South-Central University for Nationalities,Wuhan 430074,People’s Republic of China [2]The Third People’s Hospital of Datong,Datong 037000,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2021年第2期235-241,共7页应用天然产物（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(81872762);the Hubei Provincial Natural Science Foundation of China(2019CFB387).

摘　　要：Two undescribed Tricholoma triterpenoids,namely tricholopardins C(1)and D(2),were isolated from the wild mushroom Tricholoma pardinum.Their structures with absolute configurations were elucidated by spectroscopic methods,as well as the single crystal X-ray diffraction.Compounds 1 and 2 were further obtained by chemical conversions from the known analogues.Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC_(50)values of 4.7μM and 9.7μM,respectively.Its mechanism of inducing MCF-7 cell apoptosis was studied briefly.

关 键 词：Tricholoma pardinum Tricholoma triterpenoids Chemical conversion CYTOTOXICITY 

分 类 号：R285[医药卫生—中药学]