The structural basis for deadenylation by the CCR4-NOT complex  

作　　者：Mark Bartlam Tadashi Yamamoto 

机构地区：[1]Tianjin Key Laboratory of Protein Science,College of Life Sciences,Nankai University,Tianjin 300071,China [2]Division of Oncology,Institute of Medical Science,University of Tokyo,Minato-ku,Tokyo 108-8639,Japan

出　　处：《Protein & Cell》2010年第5期443-452,共10页蛋白质与细胞（英文版）

基　　金：This work was supported by the National Basic Research Program(973 Program)(Grant No.2007CB914301);the National Natural Science Foundation of China(Grant Nos.30221003 and 30770438);This work was also supported in part by the Global COE Program(Integrative Life Science Based on the Study of Biosignaling Mechanisms),MEXT,Japan.

摘　　要：The CCR4-NOT complex is a highly conserved,multifunctional machinery controlling mRNA metabolism.Its components have been implicated in several aspects of mRNA and protein expression,including transcription initiation,elongation,mRNA degradation,ubiquitination,and protein modification.In this review,we will focus on the role of the CCR4-NOT complex in mRNA degradation.The complex contains two types of deadenylase enzymes,one belonging to the DEDD-type family and one belonging to the EEP-type family,which shorten the poly(A)tails of mRNA.We will review the present state of structure-function analyses into the CCR4-NOT deadenylases and summarize current understanding of their roles in mRNA degradation.We will also review structural and functional work on the Tob/BTG family of proteins,which are known to interact with the CCR4-NOT complex and which have been reported to suppress deadenylase activity in vitro.

关 键 词：CCR4 DEAD COMPLEX 

分 类 号：R73[医药卫生—肿瘤]