Three New Compounds from the Actinomycete Actinocorallia aurantiaca  

作　　者：Kai-Yue Han Xing Wu Chenglin Jiang Rong Huang Zheng-Hui Li Tao Feng He-Ping Chen Ji-Kai Liu 

机构地区：[1]School of Pharmaceutical Sciences,South-Central University for Nationalities,Wuhan 430074,People’s Republic of China [2]State Key Laboratory for Conservation and Utilization of Bio‑Resources in Yunnan,Yunnan Institute of Microbiology,School of Life Sciences,Yunnan University,Kunming 650091,People’s Republic of China

出　　处：《Natural Products and Bioprospecting》2019年第5期351-354,共4页应用天然产物（英文）

基　　金：This work was financially supported by National Natural Science Foundation of China(Grant No.81773590).The authors thank Analytical&Measuring Centre,South-Central University for Nationalities,for the NMR measurements.

摘　　要：Aurantiadioic acids A(1)and B(2),two new furan-containing polyketides,and aurantoic acid A(3),a new natural product,were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca.The structures of the new compounds were established by extensive spectroscopic methods,including 1D&2D NMR,HRESIMS spectroscopic analysis.The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives.Biological activity evaluations suggested that compounds 1-3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC_(50)values of 35.8,41.8,45.2μM,respectively.Compound 3 showed weak inhibition on influenza A virus(A/PuertoRico/8/1934,H1N1)with an EC_(50)value of 35.9μM,and a selective index higher than 13.3.

关 键 词：ACTINOMYCETE Actinocorallia aurantiaca POLYKETIDES Anti-NO activity Antiviral activity 

分 类 号：O62[理学—有机化学]