The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1  

作　　者：Shuai Wang Jing Long Chun-fu Zheng 

机构地区：[1]State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China

出　　处：《Protein & Cell》2012年第5期372-382,共11页蛋白质与细胞（英文版）

基　　金：supported by grants from the State Key Development Program for Basic Research of China(973 Program)(Grant Nos.2010CB530105 and 2011CB504802);The Startup Fund of the 100 Talents Program from the Chinese Academy of Sciences(No.20072020-141);National Natural Science Foundation of China(Grant Nos.30870120,81171584,81101263,and 81000736)。

摘　　要：Herpes simplex virus type 1(HSV-1)is a common hu-man pathogen causing cold sores and even more se-rious diseases.It can establish a latent stage in sensory ganglia after primary epithelial infections,and reacti-vate in response to stress or sunlight.Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection.Recently,It has been deter-mined that promyelocytic leukemia(PML)nuclear bod-ies(NBs),small nuclear sub-structures,contribute to the repression of HSV-1 infection in the absence of functional ICP0.In this review,we discuss the funda-mentals of the interaction between ICP0 and PML NBs,suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.

关 键 词：herpes simplex virus type 1(HSV-1) reac-tivation ICP0 promyelocytic leukemia(PML) speckled pro-tein of 100 kDa(Sp100) 

分 类 号：R73[医药卫生—肿瘤]