Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cells  

作　　者：Zhongwei Li Ye-Guang Chen 

机构地区：[1]The State Key Laboratory of Biomembrane and Membrane Biotechnology,Tsinghua-Peking Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Protein & Cell》2012年第6期401-404,共4页蛋白质与细胞（英文版）

基　　金：supported by grants from the State Key Development Program for Basic Research of China(973 Program)(Grant Nos.2010CB833706 and 2011CB943803);the National Natural Science Foundation of China(Grant Nos.30930050 and 30921004).

摘　　要：Embryonic stem(ES)cells hold great promise in regen-erative medicine and it is an urgent task to understand the underlying molecular mechanisms that control ES cell fate choice between self-renewal and differentiation.In mouse ES cells,extrinsic leukemia inhibitory factor(LIF)and bone morphogenetic protein(BMP)signaling pathways play pivotal roles in maintaining the self-renewal status under serum and feeder free culture conditions.Intrinsic extracellularsignal regulated kinase(ERK)activity is also important in determining mouse ES cell fate-low ERK activity keeps mouse ES cell self-renewal while high ERK activity drives differentiation.

关 键 词：BMP RENEWAL INTRINSIC 

分 类 号：R73[医药卫生—肿瘤]