The differential requirement of mushroom body α/β subdivisions in long-term memory retrieval in Drosophila  

作　　者：Cheng Huang Pengzhi Wang Zhiyong Xie Lianzhang Wang Yi Zhong 

机构地区：[1]School of Life Sciences,Tsinghua University,Beijing 100084,China [2]Cold Spring Harbor Laboratory,Cold Spring Harbor,NY 11724,USA [3]Present address:Department of Biological Sciences,Stanford University,Stanford,CA 94305,USA [4]Present address:Department of Bioengineering,University of California,San Diego,La Jolla,CA 92093,USA

出　　处：《Protein & Cell》2013年第7期512-519,共8页蛋白质与细胞（英文版）

基　　金：the National Basic Research Program(973 Program)(Nos.2006CB500806 and 2009CB941301)。

摘　　要：The mushroom body(MB),a bilateral brain structure pos-sessing about 2000-2500 neurons per hemisphere,plays a central role in olfactory learning and memory in Dros-ophila melanogaster.Extensive studies have demonstrat-ed that three major types of MB neurons(α/β,α’/β’andγ)exhibit distinct functions in memory processing,including the critical role of approximately 1000 MBα/βneurons in retrieving long-term memory.Inspired by recent fi ndings that MBα/βneurons can be further divided into three subdivisions(surface,posterior and core)and wherein theα/βcore neurons play an permissive role in long-term memory consolidation,we examined the functional differ-ences of all the three morphological subdivisions of MBα/βby temporally precise manipulation of their synaptic outputs during long-term memory retrieval.We found the normal neurotransmission from a combination of MBα/βsurface and posterior neurons is necessary for retrieving both aversive and appetitive long-term memory,whereas output from MBα/βposterior or core subdivision alone is dispensable.These results imply a specifi c requirement of about 500 MBα/βneurons in supporting long-term memory retrieval and a further functional partitioning for memory processing within the MBα/βregion.

关 键 词：memory retrieval neural circuits aversive olfactory conditioning appetitive olfactory conditioning mush-room body 

分 类 号：R74[医药卫生—神经病学与精神病学]