乐山地区12082例女性人乳头瘤病毒感染及亚型分析  

Analysis of 12082 Female Human Papilloma Virus Infections and Subtypes in Leshan Area

作　　者：姚莉[1,2] 赵忠意 向尹 陶传敏 杨阳[2] 廖丹[2] 罗阳 Yao Li;Zhao Zhongyi;Xiang Yin(Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041;Department of Laboratory Medicine,Department of Pathology,People′s Hospital of Leshan,Leshan,Sichuan 614000,China)

机构地区：[1]四川大学华西医院实验医学科,四川成都610041 [2]乐山市人民医院检验科,病理科,四川乐山614000

出　　处：《四川医学》2021年第6期574-578,共5页Sichuan Medical Journal

基　　金：四川省科学技术厅重点研发项目(编号:2020YFS0136)。

摘　　要：目的研究乐山地区女性人乳头瘤病毒(human papilloma virus,HPV)感染的流行特征。方法乐山市人民医院在2017年5月至2020年5月期间对12082例妇女行HPV筛查,采用PCR-反向点杂交法进行检测。结果HPV总感染率为27.37%,其中妇产科和体检女性感染率分别为27.71%和17.22%,两组人群感染率差异有统计学意义(P<0.05)。妇产科患者HPV感染高危型主要是52、16、58、53、51、68,低危型以81、6为主;体检女性的高危型主要是53、52、58、68、39、66,低危型以81、43为主。两组均以单一高危亚型感染为主,多重感染以二重感染为主。妇产科患者不同年龄段之间的HPV感染率、多重感染率及高危型感染率差异均有统计学意义(P<0.05),且呈青春期和围绝经期双峰现象。妇产科患者的HPV感染率随时间变化呈下降趋势(P<0.05)。结论乐山地区女性HPV感染率较高,需关注21岁以下及60以上高发年龄段女性,建议疫苗研发可覆盖感染率较高的HPV53、HPV51和HPV68型别。Objective To analyze the human papilloma virus(HPV)infection,subtype distribution and age characteristics in a female population of Leshan city of Sichuan province.Methods 12,082 women who received HPV screening at Leshan People's Hospital between May of 2017 and May of 2020 were recruited,and the samples of cervical cells were detected by polymerase chain reaction(PCR)-reverse dot hybridization.Results The overall HPV positive rate was 27.37%,and the positive rate for women from obstetrics and gynecology department(27.71%)was significantly higher than those from physical examination center(17.22%)(P<0.05).High-risk(HR)HPV in obstetrics and gynecology were dominated by HPV52,HPV16,HPV58,HPV53,HPV51 and HPV68,and the low-risk HPV were mainly HPV81 and HPV 6.The predominant HR-HPV types in physical examination center were HPV53,HPV52,HPV58,HPV68,HPV39 and HPV66 and the low-risk HPV were mostly HPV81 and HPV43.Patients of the two groups were mainly infected with a single high-risk subtype of the virus,while multiple infection was mainly double infection.Differences in HPV infection rate(P<0.05),multiple infection rate(P<0.05)and HR-HPV positive rate(P<0.05)between different age groups in obstetrics and gynecology department were statistically significant,and a bimodal phenomenon was also observed.Furthermore,HPV-positive rate for obstetrics and gynecology group declined over time(P<0.05).Conclusions The HPV prevalence remains at a high level.The females under 21 and over 60 years are more likely to be infected.Current HPV vaccination should include more HPV subtypes,such as HPV53,HPV51 and HPV68.

关 键 词：人乳头瘤病毒 宫颈癌 乐山地区 

分 类 号：R737.33[医药卫生—肿瘤]