益生菌应用在神经精神障碍中的理论基础与前景展望  

The theoretical basis and prospect of probiotics application in neuropsychiatric disorders

作　　者：李素水[1] 张翠芳[1] 张亚坤 袁芳 LI Sushui;ZHANG Cuifang;ZHANG Yakun(The Eighth Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050000,China)

机构地区：[1]河北省石家庄市第八医院,050000

出　　处：《河北医药》2021年第14期2196-2200,共5页Hebei Medical Journal

基　　金：石家庄市科学技术研究与发展计划(编号:171461593)。

摘　　要：越来越多的证据支持在胃肠道、肠神经系统和中枢神经系统之间存在双向联系,被称为“肠-脑轴”。临床前期和临床试验表明,肠道微生物在肠-脑轴中起了重要作用,与应激、孤独症、抑郁症和痴呆等多种神经精神障碍的病理学机制有关。本文综述了肠-脑轴的相关机制,认为益生菌对神经精神障碍有辅助治疗作用,应推广应用。More and more evidences suggest that there exists a bilateral correlation between the gastrointestinal tract,the enteric nervous system and the central nervous system,which is called as“intestines-brain axis”.The preclinical and clinical trials have shown that intestinal microbes play an important role in intestinal-brain contact,suggesting that intestinal microorganisms paly an important role in“intestines-brain axis”,which are associated with pathological mechanisms of various neuropsychiatric disorders including stress,autism,depression and dementia.This article reviews the related mechanism of intestinal microbiota in“intestines-brain axis”,and believes that probiotics have adjuvant therapeutic effects on certain neuropsychiatric disorders,which should be used and popularized in clinical practice.

关 键 词：神经精神障碍 肠道微生物 益生菌 肠脑双向联系 

分 类 号：R749.1[医药卫生—神经病学与精神病学]