破壁松花粉联合美沙拉嗪治疗溃疡性结肠炎的疗效及对免疫功能的影响  

Clinical effect of pollen from broken wall pine combined with mesalazine in the treatment of ulcerative colitis and effect on immune function

作　　者：罗雯鹏 李克亚[1] 陆文洪[1] 王真权[1] LUO Wenpeng;LI Keya;LU Wenhong;WANG Zhenquan(Department of Anorectal,the Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410005,China)

机构地区：[1]湖南中医药大学第二附属医院肛肠科,湖南省长沙市410005

出　　处：《中南医学科学杂志》2021年第4期410-413,共4页Medical Science Journal of Central South China

基　　金：湖南省中医药管理局项目(201786);湖南省中医药重点研究室建设项目(湘中医药函[2020]51号)。

摘　　要：目的探讨破壁松花粉联合美沙拉嗪治疗溃疡性结肠炎(UC)患者的临床效果及对免疫功能的影响。方法回顾性分析55例溃疡性结肠炎患者的临床资料,将其分为美沙拉嗪组27例和破壁松花粉联合组28例,美沙拉嗪组给予美沙拉嗪口服,破壁松花粉联合组给予破壁松花粉联合美沙拉嗪口服。观察两组患者治疗前后疗效情况。结果与美沙拉嗪组比较,破壁松花粉联合组总有效率显著增高(P<0.05);结肠黏膜病变、疾病活动度、免疫功能均明显改善(P<0.05)。两组患者均未发生严重的不良反应。结论破壁松花粉联合美沙拉嗪能改善UC肠道黏膜炎症,有效控制疾病活动症状,促进机体免疫功能恢复。Aim To investigate the clinical effect and the effect on immune function of the treatment of patients with ulcerative colitis(UC)by the combination of mural pine pollen and mesalazine.Methods Retrospective analysis was performed on 55 patients with ulcerative colitis who met the criteria,with 27 patients in the mesalazine group and 28 patients in the combined group.The mesalazine group was given oral administration of mesalazine,and the combined group was given oral administration of broken pine pollen combined with mesalazine.The curative effect of two groups before and after treatment was observed.Results Compared with the mesalazine group,the total effective rate of the combined group was significantly higher(P<0.05).Colonic mucosal lesions,disease activity and immune function were significantly improved(P<0.05).No serious adverse reactions occurred in both groups.Conclusion The combination of pine pollen and mesalazine could improve intestinal mucosal inflammation of UC,effectively mesalazine the symptoms of disease activity,and promote the recovery of immune function.

关 键 词：破壁松花粉 美沙拉嗪 溃疡性结肠炎 免疫功能 

分 类 号：R574.62[医药卫生—消化系统]