无抽搐性电休克联合抗精神药物对复发精神分裂症急性期患者的临床疗效  

Clinical efficacy of modified electroconvulsive therapy combined with antipsychotics in patients with recurrent schizophrenia at acute stage

作　　者：李群 黄呈隆 蒙淑琼 周超然 LI Qun;HUANG Chenglong;MENG Shuqiong;ZHOU Chaoran(MECT Room,Nanning Fifth People's Hospital,Nanning,Guangxi 530001,China;Department of Affective Disorders,Nanning Fifth People's Hospital,Nanning,Guangxi 530001,China)

机构地区：[1]南宁市第五人民医院MECT室,广西南宁市530001 [2]南宁市第五人民医院情感障碍科,广西南宁市530001

出　　处：《中南医学科学杂志》2021年第4期477-480,共4页Medical Science Journal of Central South China

摘　　要：目的探讨无抽搐性电休克治疗(MECT)联合抗精神药物对复发精神分裂症急性期患者的临床治疗效果。方法选取130例复发精神分裂症急性期患者,随机分为对照组和联合组各65例。对照组采用抗精神药物治疗,MECT组采用MECT联合抗精神药物治疗。比较两组患者临床疗效、不良反应及治疗前后精神症状、认知功能、血浆胆碱酯酶(ChE)变化情况。结果MECT组临床总有效率优于对照组(P<0.05)。对照组和MECT组治疗后PANSS评分较治疗前明显改善,且后者改善更为显著(P<0.05)。对照组和MECT组治疗后MCCB评分明显高于治疗前(P<0.05);MECT组治疗后MCCB评分明显高于对照组(P<0.05)。对照组和MECT组治疗后ChE水平明显降低(P<0.05),MECT组治疗后ChE水平明显低于对照组(P<0.05)。两组患者不良反应发生率比较差异无显著性(χ^(2)=1.024,P=0.391)。结论无抽搐性电休克治疗联合抗精神药物对复发精神分裂症急性期患者疗效显著,其精神分裂症状、认知功能及血浆ChE水平均明显改善。Aim To investigate the clinical effect of MECT combined with antipsychotics in the treatment of patients with recurrent schizophrenia in acute stage.Methods 130 patients with acute recurrent schizophrenia were randomly divided into control group and MECT group,65 cases in each group.The control group was treated with antipsychotics,and the MECT group was treated with MECT and antipsychotics.The clinical efficacy,adverse reactions,mental symptoms,cognitive function and changes of plasma cholinesterase(ChE)before and after treatment were compared between the two groups.Results The total effective rate of the MECT group was better than that of the control group(P<0.05).The PANSS scores of the control group and the MECT group were significantly improved after treatment,and the improvement of the latter was more significant(P<0.05).MCCB score of control group and MECT group after treatment was significantly higher than that before treatment(P<0.05);The MCCB score of the MECT group was significantly higher than that of the control group after treatment(P<0.05).The level of ChE in the control group and the MECT group was significantly lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=1.024,P=0.391).Conclusion The curative effect of MECT MECT with antipsychotics in the treatment of acute stage of recurrent schizophrenia is significant,and the symptoms,cognitive function and plasma ChE level of the patients are significantly improved.

关 键 词：无抽搐性电休克治疗 抗精神药物 精神分裂症 急性期 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]