幽门螺杆菌外膜蛋白致病机制的研究进展  

Research advances on pathogenic mechanism of helicobacter pylori outer membrane protein

作　　者：陈莫耶[1] 张鑫赫 孙明军[1] CHEN Mo-ye;ZHANG Xin-he;SUN Ming-jun(Department of Gastroenterology,the First Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院消化内科,辽宁沈阳110001

出　　处：《解剖科学进展》2021年第3期367-370,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助项目(81670506);辽宁省自然科学基金计划项目(20180550049);中国医科大学附属第一医院科学研究基金(FHCMU-FSR)。

摘　　要：幽门螺杆菌(Helicobacter pylori,H.pylori)长期慢性感染能够诱发胃黏膜上皮细胞炎症反应甚至癌变,黏附定植是H.pylori致病的第一步。外膜蛋白(Outer membrane protein,OMPs)是H.pylori菌黏附定植的关键蛋白,能够通过诱发宿主细胞免疫反应以及激活细胞信号转导通路导致胃黏膜损伤。部分OMPs的生物学功能及宿主细胞受体研究已经较为深入,而且OMPs作为具有良好免疫原性的候选抗原,有望成为构建H.pylori疫苗的基础。本文就研究较为深入的OMPs及其致病机制以及相关疫苗的研究进展作以综述。Helicobacter pylori(H.pylori) long-term chronic persistent infection can induce gastric mucosal epithelial inflammation and even carcinogenesis. Attachment to the gastric mucosa is the first step for the bacterial to cause diseases. Outer membrane protein(OMPs) are crucially importantin binding to human cells and eliciting immune response and activating signaling pathways. At present, the host cell receptors of some OMPs and their biological functions have been deeply studied. OMPs are considered as suitable candidates for designing vaccines of H.pylori. This review summarizes the research progress of OMPs and its pathogenic mechanism and related vaccines.

关 键 词：H.PYLORI 胃黏膜上皮细胞 细胞信号转导通路 细胞免疫反应 候选抗原 外膜蛋白 幽门螺杆菌 致病机制 

分 类 号：R573.6[医药卫生—消化系统]