无高血压及糖尿病者脑微出血危险因素  

Risk factors for cerebral microbleeds in patients without hypertension and diabetes mellitus

作　　者：侯岚[1,2] 梁超 张舒寒 王佩 贾同乐[2,4] HOU Lan;LIANG Chao;ZHANG Shuhan;WANG Pei;JIA Tongle(Department of Neurology,Baoding NO.1 Central Hospital,Baoding 071000,China;Key Research Labo-ratory of Neurological Diseases in Baoding,Baoding 071000,China;Department of Imaging,Baoding NO.1 Central Hospital,Baoding 071000,China;Department of Neurosurgery,Baoding NO.1 Central Hospital,Baoding 071000,China)

机构地区：[1]保定市第一中心医院神经内科,河北保定071000 [2]保定市神经系统疾病研究重点实验室,河北保定071000 [3]保定市第一中心医院影像科,河北保定071000 [4]保定市第一中心医院神经外科,河北保定071000

出　　处：《医学研究与教育》2021年第3期7-11,共5页Medical Research and Education

基　　金：保定市科学技术研究与发展计划项目(17ZF264)。

摘　　要：目的探索无高血压及糖尿病患者脑微出血的危险因素。方法回顾性收集2019年4月至2020年3月于保定市第一中心医院神经内科住院并行磁敏感成像检查且未合并高血压、糖尿病患者,根据有无脑微出血分为有脑微出血组(35例)和无脑微出血组(114例)。收集2组基本资料及检查、检验结果后进行统计分析。结果单因素分析显示,年龄、收缩压在2组间差异有统计学意义(P<0.05);进一步多因素Logistic回归分析显示,患者的年龄越大(OR=1.535,95%CI=1.089~2.165,P=0.014)、收缩压越高(OR=1.715,95%CI=1.077~2.506,P=0.019),合并脑微出血的风险越高。结论年龄、收缩压是无高血压及糖尿病患者合并脑微出血的独立危险因素。Objective To explore risk factors for cerebral microbleeds(CMB)in patients without hypertension and diabetes.Methods Patients hospitalized in the Department of Neurology,Baoding NO.1 Central Hospital from April 2019 to March 2020 without hypertension and diabetes were retrospectively recruited.Each patient underwent MRI check including susceptibility-weighted imaging(SWI).They were divided into two groups according to the existence of CMBs named CMB group(with CMBs,n=35)and NCMB group(without CMBs,n=114)respectively.Clinical and neuroimaging information was collected.Statistical analysis was conducted thereafter.Results It was demonstrated by univariate analysis that age,systolic blood pressure and systolic-todiastolic pressure were associated with CMBs(P<0.05).Multivariate Logistic regression analysis showed that the older of the patient,the results of the experimental subjects would become(OR=1.535,95%CI=1.089-2.165,P=0.014)and the higher systolic blood pressure(OR=1.715,95%CI=1.077-2.506,P=0.019),the higher risk of CMB.Conclusion Age and systolic blood pressure were independent risk factors for CMBs in patients without hypertension and diabetes.

关 键 词：脑微出血 危险因素 高血压 糖尿病 

分 类 号：R74[医药卫生—神经病学与精神病学]