上海/宁夏及重庆地区儿童腺样体肥大与EBV感染相关性的初步研究  

Relevance of EBV infection and children adenoid hypertrophy in Shanghai,Ningxia and Chongqing

作　　者：周恩晖 张燚[1] 马瑞霞[2] 伍立德 陈晓平[1] Zhou Enhui;Zhang Yi;Ma Ruixia;Wu Lide;Chen Xiaoping(Department of Otorhinolaryngology,Shanghai Pudong New Area Gongli Hospital,Shanghai,Pudong,200135;Department of Otorhinolaryngology,General Hospital of Ningxia Medical University,Gansu,Ningxia,750004;Department of Otorhinolaryngology,Chongqing Wanzhou Shanghai Hospital,Chongqing,Wanzhou,404000,China)

机构地区：[1]上海市浦东新区公利医院,上海浦东200135 [2]宁夏医科大学附属总医院耳鼻咽喉头颈外科,甘肃宁夏750004 [3]重庆万州上海医院耳鼻咽喉头颈外科,重庆万州404000

出　　处：《中国医学文摘（耳鼻咽喉科学）》2021年第3期119-121,共3页Chinese Medical Digest(Otorhinolaryngology)

基　　金：浦东新区卫生系统医学人才培养计划(项目编号:PWRq2020-50);上海市浦东新区公利医院人才培养计划(项目编号:GLRq2020-01)。

摘　　要：目的探讨不同地区儿童腺样体肥大与EBV感染的相关性及地域差异性。方法取儿童腺样体肥大标本224例,其中上海65例、宁夏104例、重庆55例,应用实时荧光定量PCR技术对样本行EBV定量检测。结果儿童腺样体肥大标本中EBV感染总阳性率为64.7%,其中上海、宁夏及重庆地区EBV感染阳性率分别为52.31%(34/65)、69.23%(72/104)和70.91%(39/55),上海地区与宁夏及重庆地区EBV感染阳性率比较有统计学意义(P<0.05),不同性别与EBV感染阳性率之间差异无明显统计学意义(P>0.05)。结论儿童腺样体肥大的发病与EBV感染密切相关,西部地区EBV感染率显著升高,而腺样体肥大患儿的性别、年龄与EBV感染无关,为儿童腺样体肥大的早期预防与精准治疗提供了新思路。Objective To observe the relationship between EBV Infection and Children Adenoid Hypertrophy and territorial variation.Methods This study included 224 children adenoid hypertrophy specimens(65 from Shanghai,104 from Ningxia,55 from Chongqing),which have been collected by surgical therapy.The specimens had been detected the quantity of EBV using real-time fluorescent quantitative PCR(RT-PCR).Results Total infectious rate is 64.7%,including 52.31%of Shanghai,69.23%of Ningxia,70.91%of Chongqing,Shangai group infectious rate was significantly lower than that in Ningxia and Chongqing group.Conclusion The EBV contributes to the pathogenesis of children adenoid hypertrophy and western areas have more susceptibility.

关 键 词：儿童腺样体肥大 EBV 实时荧光定量PCR 

分 类 号：R73[医药卫生—肿瘤]