强迫症患者脑灰质基于体素的形态学研究  

Voxel-based morphometry analysis of gray matter in patients with obsessive-compulsive disorder

作　　者：陶甜美 王国强 吴明飞[1] TAO Tian-mei;WANG Guo-qiang;WU Ming-fei(The Fourth People's Hospital of Wuhu,Wuhu,Anhui Province 240000,China)

机构地区：[1]芜湖市第四人民医院,安徽芜湖240000

出　　处：《解剖学研究》2021年第3期251-256,共6页Anatomy Research

摘　　要：目的运用基于体素的形态学测量(VBM)分析方法研究强迫症患者大脑灰质体积的改变,以及强迫症患者大脑灰质体积和耶鲁布朗强迫量表(Y-BOCS)评分的相关性。方法收集20例未服药强迫症患者和20例健康对照组,对被试的大脑结构进行磁共振扫描。采用VBM分析方法对所获得的数据进行统计分析。结果(1)强迫症患者组较对照组在3个MNI坐标点的灰质体积显著增加;(2)经过多重比较校正后发现,强迫症患者灰质体积减小的脑区有:右侧罗兰迪克岛盖、中央前回、中央后回、右侧颞极、左侧枕下回、左侧枕中回、右侧小脑以及双侧直回(P<0.05);(3)以颅内体积为协变量,对强迫症患者大脑灰质体积与Y-BOCS评分作回归分析发现,患者右侧额中回、左侧内侧额上回、左侧背外侧额上回、右侧罗兰迪克岛盖、双侧眶额叶下回、右侧眶额叶中回、右侧颞中回、右侧颞极、小脑、左侧脑岛以及小脑的蚯体的灰质体积与Y-BOCS评分存在负相关(P<0.05);(4)发现强迫症患者灰质体积减小的脑区的灰质体积与Y-BOCS量表呈负相关的脑区有重叠部分,分别位于右侧颞极、右侧小脑、右侧罗兰迪克岛盖。结论(1)强迫症患者灰质体积存在异常,主要表现大脑皮质灰质体积的减小;(2)除皮质-纹状体-丘脑-皮质环路的结构异常外,大脑的后部区域如顶叶、颞叶、枕叶和小脑灰质体积减小可能与强迫症的发病机制相关;(3)强迫症患者症状严重程度与大脑部分脑区灰质体积的改变成显著负相关。Objective To explore the neuroanatomical changes in patients with obsessive-compulsive disorder(OCD)using the voxel-based morphometry(VBM)analysis.We also aimed to explore the relationship between the gray matter volume and Yale Brown Obsessive Compulsive Scale(Y-BOCS)score in patients with obsessive-compulsive.Methods We recruited 20 drug-na?ve patients with OCD and 20 healthy controls,We employed the voxel-based morphometry(VBM)approach to explore the neuroanatomical changes in patients.We also investigated the relationship between the gray matter volume and Yale Brown Obsessive Compulsive Scale(Y-BOCS)score in patients with obsessive-compulsive.Results(1)Compared with healthy controls,patients with OCD showed significantly increased gray matter in three point MNI coordinates,but we don’t found specific regions of the brain in ALL template.(2)Results after correction for multiple comparisons found in patients with obsessive-compulsive disorder,gray matter volume reduction of brain regions:the right central sulcus cover,right precentral gyrus,right postcentral gyrus,temporal pole,right middle occipital gyrus,left middle occipital gyrus,right cerebellum and bilateral straight gyrus(P<0.05).(3)We choose the intracranial volume as a covariant,regression analysis between brain gray matter volume of OCD patients and Y-BOCS score.We found that the right middle frontal gyrus,left medial frontal gyrus,left superior frontal gyrus,right dorsolateral frontal gyrus,right rolandic operculum,the bilateral inferior orbitofrontal gyrus,the right medial orbitofrontal gyrus,right middle temporal gyrus,the right temporal pole gyrus,cerebellum,left insula of the gray matter volume and Y-BOCS score negatively correlated(P<0.05).(4)We also found a distinct set of overlapped brain regions between brain regions with GMV reductions and brain regions whose GMV was correlated with Y-BOCS score negatively in patients with OCD:the right temporal pole,the right cerebellum,and the right rolandic operculum.Conclusion(1)The gray matter volume

关 键 词：强迫症 磁共振成像 灰质体积 形态学测量 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]