非肥胖非酒精性脂肪性肝病生物化学指标及危险因素分析  

Analysis of biochemical indexes and risk factors of non obese and nonalcoholic fatty liverdisease

作　　者：梁灿灿[1,2] 王玥 柯月[2] 纪文静[2] 姚萍[1] LIANG Can-can;WANG Yue;KE Yue;JI Wen-jing;YAO Ping(Department of Gastroenterology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,830054,China;Department of Gastroenterology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi,830063,China;Disease Control and Prevention Center,Xinjiang production and Construction Corps,Urumqi,830002,China;School of Public Health,Xinjiang Medical University,Urumqi,830054,China)

机构地区：[1]新疆医科大学第一附属医院,乌鲁木齐830054 [2]新疆医科大学第二附属医院,乌鲁木齐830063 [3]新疆生产建设兵团疾病预防控制中心,乌鲁木齐830002 [4]新疆医科大学公共卫生学院,乌鲁木齐830054

出　　处：《新疆医学》2021年第4期384-387,共4页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区省部共建中亚高发病成因与防治国家重点实验室开放课题(项目编号:SKL-HIDCA-2020-48);新疆维吾尔自治区自然科学基金面上项目(项目编号:2019D01C230)。

摘　　要：目的探讨非肥胖非酒精性脂肪性肝病(NAFLD)患者生物化学指标及危险因素,以期为非肥胖NAFLD临床诊断和防治提供依据。方法随机纳入非肥胖NAFLD患者20例、肥胖NAFLD患者20例、健康体检者20例和代谢正常肥胖者20例,检测其腰围及血清中血红蛋白、红细胞、白细胞、血小板、空腹血糖、肌酐、尿素氮、尿素,用酶联免疫吸附法检测血清中短链脂肪酸(SCFA)、白介素-17(IL-17)。方差分析、t检验分析4组相关指标水平差异,危险因素分析采用多因素logistics回归分析。结果非肥胖NAFLD组、肥胖NAFLD组、健康对照组、代谢正常肥胖对照组中HB、尿酸水平,存在统计学差异(P=0.023、P=0.017)。BMI、尿酸是影响非肥胖NAFLD发病的独立危险因素(OR值分别为1.09、1.01)。非肥胖NAFLD组和肥胖NAFLD组血清SCFA水平均高于健康对照组、代谢正常肥胖对照组,差异均有统计学意义(P <0.05);非肥胖NAFLD组血清SCFA水平低于肥胖NAFLD组,差异有统计学意义(P <0.05)。Objective To investigate the biochemical indexes and risk factors of nonobese patients with nonalcoholic fatty liver disease(NAFLD), in order to provide the basis for clinical diagnosis, prevention and treatment of non obese NAFLD. Methods 20 nonobese NAFLD patients, 20 obese NAFLD patients, 20 healthy people and 20 normal metabolic obese patients were randomly selected.Their waist circumference and serum hemoglobin, red blood cells, white blood cells, platelets, fasting blood glucose, creatinine, urea nitrogen and urea were detected. Serum short chain fatty acid(SCFA)and interleukin-17(IL-17)were detected by enzyme-linked immunosorbent assay. Analysis of variance and t-test were used to analyze the related indexes among four groups. Multivariate logistic regression analysis was used to analyze the risk factors. Results The levels of Hb and uric acid in four groups were statistically different(P = 0.023, P = 0.017). BMI and uric acid were independent risk factors for NAFLD(or=1.09 and 1.01, respectively). The serum SCFA levels of non obese NAFLD group and obese NAFLD group were higher than those of healthy control group and normal metabolism obesity control group, and the difference was statistically significant(P < 0.05). The serum SCFA level of nonobese NAFLD group was lower than that of obese NAFLD group, the difference was statistically significant(P < 0.05).

关 键 词：非肥胖 非酒精性脂肪性肝病 短链脂肪酸 危险因素 

分 类 号：R575.1[医药卫生—消化系统]