Her-2、ER、PR、ki-67与乳腺癌淋巴结转移及病理分级的相关性研究  

Correlation between Her-2, ER, PR, ki-67 and lymph node metastasis and pathological grade of breast cancer

作　　者：郭灵敏[1] 谷小玉 李林株[1] 杜佩铭 区承昌 GUO Lingmin;GU Xiaoyu;LI Linzhu;DU Peiming;OU Chengchang(People's Hospital of Gaoming District,Foshan,Guangdong 528500,China)

机构地区：[1]佛山市高明区人民医院,广东佛山528500

出　　处：《新疆医学》2021年第4期452-454,共3页Xinjiang Medical Journal

摘　　要：目的探讨Her-2、ER、PR、ki-67与乳腺癌淋巴结转移及病理分级的相关性。方法选取本院2017年2月-2020年2月收治的乳腺癌患者110例为研究对象,所有患者均符合乳腺癌病理诊断标准,并行Her-2、ER、PR、ki-67免疫组化检测,比较淋巴结转移与否、病理组织学分级间各指标的表达情况。结果随着病理组织学分级升高Her-2阳性程度及阳性细胞量均升高,Ki-67阳性率也与病理分级呈正比,而ER-PR则随着病理分级的升高表达逐渐降低。淋巴结阳性患者Her-2和Ki-67表达均显著高于阴性患者,而ER、PR则与之相反。结论 Her-2、ER、PR、ki-67可反映乳腺癌的部分病理特征,可有效反映患者预后,为临床制定科学、有效的治疗方案提供参考。Objective To investigate the correlation between her-2, ER, PR, ki-67 and lymph node metastasis and pathological grade of breast cancer. Methods 110 cases of breast cancer patients admitted to our hospital from February 2017 to February 2020 were selected as the study object. All the patients met the pathological diagnostic criteria of breast cancer. Immunohistochemical detection of her-2, ER, PR and ki-67 was conducted in the same time. Results With the increase of histopathological grade, both the positive degree of her-2 and the number of positive cells increased, the ki-67 positive rate was proportional to the pathological grade, and the expression of er-pr decreased with the increase of pathological grade. The expressions of her-2 and ki-67 in patients with positive lymph nodes were significantly higher than that of patients with negative lymph nodes, while ER and PR were in contrast. Conclusions Her-2,ER, PR and ki-67 can reflect part of the pathological features of breast cancer, effectively reflect the prognosis of patients, and provide reference for clinical development of scientific and effective treatment plans.

关 键 词：乳腺癌 免疫组化 淋巴结转移 病理分级 

分 类 号：R739.9[医药卫生—肿瘤]