Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori  

作　　者：Jiangbo Song Lian Liu Kaige Hao Shuang Mao Yongxi Tang Xiaoling Tong Fangyin Dai 

机构地区：[1]State Key Laboratory of Silkworm Genome Biology,Key Laboratory for Sericulture Biology and Genetic Breeding,Ministry of Agriculture and Rural Affairs,College of Biotechnology,Southwest University,No.2 Tiansheng Road,Beibei District,Chongqing,400715,China

出　　处：《Journal of Pharmaceutical Analysis》2021年第3期374-382,共9页药物分析学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.31830094 and 31902215);the Hi-Tech Research and Development 863 Program of China(Grant No.2013AA102507);the Fundamental Research Funds for the Central Universities in China(No.XDJK2019C014);Project funded by Chongqing Special Postdoctoral Science Foundation(Grant No.XmT2018058);Funds of China Agricultural Research System(No.CARS-18-ZJ0102)。

摘　　要：A number of research has shown that the plant polyphenol resveratrol,one of the most prominent small molecules,has beneficial protective effects in multiple organisms,including worms,flies,and killifish.To understand the effects of resveratrol on lifespan,we evaluated its effects in the silkworm Bombyx mori.In this study,we found that lifespan was significantly prolonged in both female and male silkworms treated with resveratrol.Silkworm larval weight was significantly increased from day 3 of the 5th larval instar(L5D3)to day 7 of the 5th larval instar(L5D7).However,the weight of the pupa,cocoon,and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in controls.Meanwhile,resveratrol significantly improved the thermotolerance of the silkworms,which enhanced their survival rate.Moreover,antioxidant activity was increased by resveratrol in both female and male silkworms.Furthermore,an antioxidant-related signalling pathway,SIRT7-FoxO-GST,was activated in silkworms with resveratrol treatment.Collectively,these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.

关 键 词：RESVERATROL Bombyx mori LIFESPAN Antioxidant activity SIRT7-FoxO-GST pathway 

分 类 号：R285.5[医药卫生—中药学]