One-pot tandem route to fused indolizidines and quinolizidines:Application in the synthesis of alkaloids and bioactive compounds  

作　　者：Qiao Song Yan Liu Linlin Cai Xinyu Cao Shan Qian Zhouyu Wang 

机构地区：[1]Department of Pharmaceutics Engineering,Xihua University,Chengdu 610039,China [2]Department of Chemistry,Xihua University,Chengdu 610039,China

出　　处：《Chinese Chemical Letters》2021年第5期1713-1716,共4页中国化学快报（英文版）

基　　金：We are grateful for the financial support from the National Natural Science Foundation of China(No.81973189);Sichuan Outstanding Young Scientific and Tech no logical Talents Project(No.2020JDJQ0054);Sichuan Science and Technology Program(No.19ZDYF0890);Scientific Research Foundation of the Education Department of Sichuan Province(No.18TD0023);Xihua University Talents Project(No.Z202030).

摘　　要：Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds.A one-pot tan dem route from amide to fused indolizidines and quinolizidines is disclosed.This method is con ducted in mild conditions and shows well tolerance of functional groups.It is also easy to be scaled up to gram scale and can be applied smoothly to the total synthesis of alkaloids such as(±)-crispine A,(±)-xylopinine,(±)-desbromoarborescidine A,(±)-harmicine and other bioactive substances.

关 键 词：ONE-POT INDOLIZIDINES QUINOLIZIDINES Scalable ALKALOIDS 

分 类 号：O621.25[理学—有机化学]