Covalent organic framework nanoparticles for anti-tumor gene therapy  

作　　者：Kai Hao Zhaopei Guo Lin Lin Pingjie Sun Yanhui Li Huayu Tian Xuesi Chen 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]University of Science and Technology of China,Hefei 230026,China [3]School of Materials Science and Engineering,Changchun University of Science and Technology,Changchun 130022,China [4]Jilin Biomedical Polymers Engineering Laboratory,Changchun 130022,China

出　　处：《Science China Chemistry》2021年第7期1235-1241,共7页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(51925305,51873208,51520105004,51833010,51803210,51803014);the National Science and Technology Major Projects for Major New Drugs Innovation and Development(2018ZX09711003-012);Jilin Province Science and Technology Development Program(20180414027GH)。

摘　　要：Covalent organic framework(COF)materials have great development value in the biomedical field.However,the huge size and poor dispersion of COF materials severely limit their application.Here we successfully prepared COF nanoparticles with uniform size and good dispersion under the assistance of microwave.By adding some cationic polymers or small amine molecules,the dispersibility of COF could be further improved and its surface charge also increased.The prepared cationic COF nanoparticles(CLZU NPs)had excellent gene transfection ability and good biocompatibility.Designing low-toxic and highefficiency gene carrier is an important mission in the field of gene therapy.This COF-based gene vector provides a new direction for gene carrier design.

关 键 词：COF CATIONIC gene therapy 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]