缺血预/后处理对肠缺血再灌注损伤保护作用的研究进展  

Research progress of protective effect of ischemic preconditioning/postconditioning on intestinal ischemia-reperfusion injury

作　　者：卓明[1] 叶军明[1] 王万辉[1] 钟茂林[1] 刘金龙[1] ZHUO Ming;YE Jun-ming;WANG Wan-hui;ZHONG Mao-lin;LIU Jin-long(Anesthesiology Department,the First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院第一附属医院麻醉科,江西赣州341000

出　　处：《赣南医学院学报》2021年第6期633-638,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：肠缺血再灌注(Ischemic reperfusion,IR)损伤多见于失血性休克、大面积烧伤、体外循环、小肠或肝移植等常见病理生理过程,可直接引起肠黏膜损伤、肠黏膜屏障功能障碍,还可进一步引起远端脏器损伤、多器官功能障碍综合征(Multiple organ dysfunction syndrome,MODS)甚至死亡。缺血预处理(Ischemic preconditioning,IPC)及缺血后处理(Ischemic postconditioning,IPO)分别指发生IR前/后给予反复、短暂的缺血再灌注,诱导机体产生内源性保护机制,增强组织器官对IR的耐受能力,减轻损伤。目前,关于缺血预/后处理对肠IR的保护作用相关研究已较为多见,本文对肠IR发生机制、缺血预/后处理方案及作用机制等进行综述。Intestinal ischemia-reperfusion(IR)injury are common in pathological physiological processes such as uncontrolled hemorrhagic shock,more extensive burns,extracorporeal circulation,small intestine or liver transplantation.It can directly cause intestinal mucosa injury and dysfunction of intestinal mucosa,and can even cause distal viscera injury,multiple organ dysfunction syndrome(MODS)even death.Ischemic preconditioning(IPC)and Ischemic postconditioning(IPO)respectively refer to an application of repeated ischemic reperfusion before and after IR,which can effectively induce the endogenous protection mechanism of the body and enhance the tolerance of tissues and organs to IR,and reduce injury.At present,there have been many studies on the protective effect of ischemic pretreatment/posttreatment on intestinal IR.This article will review the mechanism of intestinal IR occurrence,ischemic pretreatment/posttreatment and the mechanism of action.

关 键 词：肠缺血再灌注 缺血预处理 缺血后处理 多器官功能障碍综合征 

分 类 号：R574[医药卫生—消化系统]