表皮生长因子受体表达水平与甲状腺乳头状癌疾病进展的相关性的meta分析  

Correlation between the expression of epidermal growth factor receptor and progression of papillary thyroid carcinoma:a meta analysis

作　　者：朱玉娇 李玥 宋守君[1] 薛海波[1] Zhu Yujiao;Li Yue;Song Shoujun;Xue Haibo(Department of Endocrinology,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院内分泌科,山东256603

出　　处：《国际医药卫生导报》2021年第14期2056-2061,共6页International Medicine and Health Guidance News

基　　金：山东省重点研发计划项目(2016GSF201021);滨州医学院附属医院科研创新团队项目(202031);滨州医学院附属后备领军人才项目(JC2019-03)。

摘　　要：目的通过meta分析探讨表皮生长因子受体(epidermalgrowthfactorreceptor,EGFR)表达水平与甲状腺乳头状癌(papillarythyroidcarcinoma,PTC)患者淋巴结转移、远处转移及临床分期等临床特征的相关性。方法通过PubMed、Medline、Embase、Cochrane图书馆、SinoMed、中国知网、万方、维普等数据库检索2020年10月之前发表的EGFR与PTC相关的文献,将符合纳入标准的文献应用RevMan 5.3及STATA 12.0软件进行统计学分析,计算出比值比(OR)及95%置信区间(CI),并进行了发表偏倚检测及敏感性分析。结果本meta分析共纳入7项研究,涉及636例PTC患者。分析显示,EGFR高表达与PTC淋巴结转移(OR=4.88,95%CI:3.29~7.24;合并效应量检验,Z=7.86,P<0.00001)、远处转移(OR=4.12,95%CI:1.52~11.19;合并效应量检验,Z=2.78,P=0.005)、肿瘤长径(OR=2.23,95%CI:1.25~3.98;合并效应量检验,Z=2.72,P=0.007)以及临床分期(OR=2.30,95%CI:1.47~3.60;合并效应量检验,Z=3.66,P=0.0002)均呈显著正相关,但与患者性别无明显相关性(OR=0.95,95%CI:0.63~1.43;合并效应量检验,Z=0.27,P=0.79)。结论EGFR高表达可能在PTC肿瘤进展中发挥重要作用,对PTC预后评估及药物选择具有一定的临床意义。Objective Meta-analysis was conducted to explore the correlation between the expression level of epidermal growth factor receptor(EGFR)and the clinical features of patients with papillary thyroid carcinoma(PTC),such as lymph node metastasis,distant metastasis,and clinical stage.Methods Literatures related to EGFR and PTC published before October 2020 were retrieved from the databases of PubMed,Medline,Embase,Cochrane library,SinoMed,China National Knowledge Infrastructure(CNKI),Wanfang,and VIP.The literatures according with the inclusion criteria were analyzed by RevMan 5.3 and STATA 12.0 software.The odds ratio(OR)and corresponding 95%confidence interval(CI)were calculated,the publication bias was examined,and the sensitivity was analyzed.Results In the present meta analysis,7 articles,involving 636 patients with PTC,were selected.The analysis showed that EGFR overexpression was significantly correlated with lymph node metastasis(OR=4.88,95%CI:3.29-7.24;combined effect test,Z=7.86,P<0.00001),distant metastasis(OR=4.12,95%CI:1.52-11.19;combined effect test,Z=2.78,P=0.005),tumor length(OR=2.23,95%CI:1.25-3.98;combined with effect test,Z=2.72,P=0.007),and clinical stage(OR=2.30,95%CI:1.47-3.60;combined effect test,Z=3.66,P=0.0002)in the patients with PTC,but there was no significant correlation between EGFR level and gender(OR=0.95,95%CI:0.63-1.43;combined effect test,Z=0.27,P=0.79).Conclusion The high expression of EGFR may play an important role in the progression of PTC,which may have significant value for the clinical prognostic evaluation and treatment selection of PTC.

关 键 词：表皮生长因子受体 甲状腺乳头状癌 META分析 转移 临床分期 

分 类 号：R736.1[医药卫生—肿瘤]