泪道U形置管术联合地塞米松注射液冲洗治疗泪道阻塞40例  

Lacrimal duct U-shaped catheterization combined with dexamethasone in treating 40 cases of lacrimal duct obstruction

作　　者：张晓莉[1] 于泓[1] 韩冬梅[1] 杨瑞民[1] 戚伟[1] ZHANG Xiaoli;YU Hong;HAN Dongmei;YANG Ruimin;QI Wei(Department of Ophthalmology,The People's Hospital of Langfang,Langfang,Hebei 065000,China)

机构地区：[1]廊坊市人民医院眼科,河北廊坊065000

出　　处：《安徽医药》2021年第8期1663-1666,共4页Anhui Medical and Pharmaceutical Journal

基　　金：廊坊市科技支撑计划项目(2015013005C)。

摘　　要：目的探讨泪道U形置管联合地塞米松治疗泪道阻塞的临床效果及安全性。方法选取2017年1月至2018年1月在廊坊市人民医院就诊的泪道阻塞病人80例(104眼),采用随机数字表法分为联合组(泪道U形置管联合地塞米松注射液治疗)和对照组(泪道U形置管治疗)各40例,对比两组治疗前后不同时间点泪液分泌量、泪膜破裂时间及两组临床疗效、并发症率。结果联合组和对照组的泪液分泌量治疗前[(14.4±2.7)mm/5min比(15.0±2.4)mm/5min]、治疗1个月后[(19.2±3.1)mm/5min比(20.0±3.5)mm/5min]比较,差异无统计学意义(P>0.05);拔管后,联合组的泪液分泌量低于对照组[(11.3±2.7)mm/5min比(13.2±2.5)mm/5min,P<0.05],两组拔管后的泪液分泌量均较治疗前降低(P<0.05);治疗前、治疗1个月、拔管后,两组不同时间点之间泪膜破裂时间比较,均差异无统计学意义(P>0.05);治疗后,联合组痊愈率76.92%、好转率23.08%,对照组痊愈率53.85%、好转率44.23%、无效率1.92%,联合组临床疗效优于对照组(P<0.05);治疗过程中,联合组的并发症率3.85%低于对照组的19.23%(P<0.05)。结论泪道U形置管联合地塞米松治疗泪道阻塞的效果优于单用泪道U形置管,且具有降低并发症的优势。Objective To investigate the clinical effect and safety of lacrimal duct U-shaped tube combined with dexamethasone in the treatment of lacrimal duct obstruction.Methods Eighty patients(104 eyes)who were treated in the People’s Hospital of Langfang form January 2017 to January 2018 were selected as the research object,and they were assigned into the combined group(lacrimal duct U-tube combined with dexamethasone treatment)and the control group(lacrimal duct U-shaped tube),with 40 cases in each group.The difference of tear secretion,tear film rupture time,clinical efficacy difference and complication rate between the two groups of patients at different time points before and after treatment were compared.Results The tear secretion in the combined group and the control group before treatment[(14.4±2.7)mm/5 min vs.(15.0±2.4)mm/5 min]and after 1 month of treatment[(19.2±3.1)mm/5 min vs.(20.0±3.5)mm/5 min]was detected,and there was no statistically significant difference.After extubation,the tear secretion in the combined group was lower than that in the control group[(11.3±2.7)mm/5 min vs.(13.2±2.5)mm/5 min,P<0.05],and the tear secretion after extubation in both groups was lower than before treatment(P<0.05).Before treatment,1 month after treatment,and after extubation,the tear film rupture time of the combined group and the control group was compared between the two groups and at different time points,and there was no statistically significant difference(P>0.05).After treatment,the recovery rate of the combined group was 76.92%,the improvement rate was 23.08%,the control group was 53.85%,the improvement rate was 44.23%,and the inefficiency was 1.92%.The clinical efficacy of the combination group was better than the control group(P<0.05).During treatment,the complication rate of the combined group(3.85%)was lower than 19.23%of the control group(P<0.05).Conclusion The lacrimal duct U-shaped tube combined with dexamethasone is better than lacrimal duct U-shaped tube alone in treating lacrimal duct obstruction,an

关 键 词：泪器阻塞 泪道U形置管 地塞米松 鼻泪管 临床效果 安全性 

分 类 号：R779.6[医药卫生—眼科]