Overflow phenomenon in serum lutein after supplementation:a systematic review supported with SNPs analyses  

作　　者：Abdulrahman M Alharbi Mohammed A Kilani Tos TJM Berendschot 

机构地区：[1]Clinical Biochemistry Unit,Department of Pathology and Laboratory Medicine,College of Medicine,King Saud University,Riyadh 11451,Saudi Arabia [2]Public Health Authority of Saudi Arabia,Riyadh 13352,Saudi Arabia [3]University Eye Clinic,Maastricht University Medical Center,Maastricht 6229HX,The Netherlands

出　　处：《International Journal of Ophthalmology(English edition)》2021年第7期1114-1119,共6页国际眼科杂志（英文版）

基　　金：Supported by DSR Scholarship Support,King Saud University。

摘　　要：Lutein,a type of carotenoids,is found to delay the onset and progression of age-related macular degeneration(AMD).Several lutein supplementation studies showed that after an initial increase,lutein serum levels demonstrated a subsequent decrease despite continuous supplementation.In this systematic literature review,this obscure phenomenon was tried to be explained.The subsequent drop in lutein levels was postulated due to down-regulation of lutein receptors scavenger receptor class B typeⅠ(SR-BI)in the gastrointestinal tract,upregulation of lutein degrading enzymeβ-carotene dioxygenase(BCDO2),or perhaps a combination of both.Some single nucleotides polymorphisms(SNPs)that could have influence on the occurrence of this phenomenon.To date,an exact scientific explanation for this phenomenon has not been established.Further research is needed to investigate this phenomenon in depth to reach an irrefutable explanation,giving that lutein is proven to be effective in delaying the onset and progression of AMD and its metabolism in the human body becomes of equal importance.

关 键 词：LUTEIN macular degeneration carotenoids XANTHOPHYLLS β-carotene dioxygenase scavenger receptor class B typeⅠ 

分 类 号：R774.5[医药卫生—眼科]