Cathepsin L mediates glomerular endothelial cell injury by cleavaging complement C3 in trichloroethylene-sensitized mice  

作　　者：HUANG Meng 黄猛(Dept Occup&Environm Health,Sch Public Health,Anhui Med Univ,Hefei 230032)

机构地区：[1]Dept Occup&Environm Health,Sch Public Health,Anhui Med Univ,Hefei 230032

出　　处：《China Medical Abstracts(Internal Medicine)》2021年第2期80-80,共1页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To observe the expressions of complement3(C3)and endothelial cell injury-associated proteins before and after cathepsin L(CTSL)blockade in renal injury of trichloroethylene(TCE)-sensitized mice.Methods In June 2018,41 SPF female BALB/c mice were divided respectively into blank control group(n=5),vehicle control group(n=5),TCE group(n=15)and TCE+CTSLi group(n=16)to establish trichloroethylene-sensitized mice model by pretreating the mice with intraperitoneal injection of CTSL inhibitor(CTSLi)and using TCE for the first and last challenge.

关 键 词：INJECTION CATHEPSIN INJURY 

分 类 号：R692[医药卫生—泌尿科学]