自身免疫性肝病相关自身抗体检测的临床应用专家共识  

Expert consensus on clinical application of autoantibodies detection in patients with autoimmune liver disease

作　　者：无 曾小峰[4] 胡朝军[4] 周仁芳 李晞[6] 何敏[7] 刘冬舟 赵久良[4] 杨滨[9] 无;Zeng Xiaofeng(The Committee of the Autoantibodies Detection of Rheumatology and Immunology Physicians Committee of Chinese Medical Doctor Association;Chinese Rheumatism Data Center;National Clinical Research Center for Dermatologic and Immunologic Diseases;Department of Rheumatology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医师协会风湿免疫科医师分会自身抗体检测专业委员会 [2]国家风湿病数据中心 [3]国家皮肤与免疫疾病临床医学研究中心 [4]中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,100730 [5]温州医科大学附属温岭医院检验科 [6]广西医科大学第一附属医院检验科 [7]广东省中医院检验科 [8]深圳市人民医院风湿免疫科 [9]四川大学华西医院实验医学科

出　　处：《中华内科杂志》2021年第7期619-625,共7页Chinese Journal of Internal Medicine

基　　金：国家自然科学基金(81771780);中国医学科学院医学与健康科技创新工程(2017-I2M-3-001);国家重点研发计划(2019YFC0840603、2017YFC0907601、2017YFC0907602)。

摘　　要：自身免疫性肝病是一组由异常自身免疫介导的肝胆炎症性疾病,主要包括自身免疫性肝炎、原发性胆汁性胆管炎、原发性硬化性胆管炎及上述任何两种疾病主要特征同时出现的重叠综合征等。自身免疫性肝病相关自身抗体检测临床应用的标准化,有助于疾病的诊断与分类、预测预后、病情监测及发病机制的研究。Autoimmune liver disease is a group of hepatobiliary inflammatory diseases mediated by abnormal autoimmunity,mainly including autoimmune hepatitis,primary biliary cholangitis,primary sclerosing cholangitis and overlap syndrome of any two of the above diseases at the same time.The standardization of clinical application of autoantibody detection related to autoimmune liver disease is helpful to the diagnosis and classification of diseases,as well as the prediction of prognosis,disease monitoring and pathogenesis research.

关 键 词：自身免疫性肝病 自身抗体 自身免疫性肝炎 原发性胆汁性胆管炎 胆管炎 硬化性 

分 类 号：R575[医药卫生—消化系统] R446.6[医药卫生—内科学]