布拉氏酵母菌的作用机制及其在溃疡性结肠炎中应用的研究进展  

Research progress of mechanism of action of Saccharomyces boulardii and its application in ulcerative colitis

作　　者：史刚刚[1] 韩梅 郝敬鹏[1] 郑冰 Shi Ganggang;Han Mei;Hao Jingpeng;Zheng Bing(Department of Colorectal Surgery,the Second Hospital of Tianjin MedicalUniversity,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院肛肠外科,300211

出　　处：《国际生物医学工程杂志》2021年第2期163-167,共5页International Journal of Biomedical Engineering

基　　金：天津市卫生健康科技项目(ZC20154)。

摘　　要：布拉氏酵母菌(Saccharomyces boulardii)是啤酒酵母菌的一个亚种,为真菌类益生菌。其可以调节肠道菌群,增强肠道的屏障功能。同细菌类益生菌相比,布拉氏酵母菌更耐酸、耐氧化、不与细菌发生遗传物质传递,还可以同抗生素合用。布拉氏酵母菌可以通过多种机制发挥作用,其分泌的许多蛋白酶具有抗毒素作用;其自身菌体含有较多多胺类物质,可以营养肠道黏膜细胞,调节机体代谢平衡;可以通过调控多个信号通路增强肠道免疫。布拉氏酵母菌已经被应用于溃疡性结肠炎(UC)的治疗。动物实验和临床研究结果均显示,应用布拉氏酵母菌可以改善肠道炎症,增强美沙拉嗪的治疗效果,布拉氏酵母菌可作为UC治疗的辅助用药。Saccharomyces boulardii is a subspecies of Saccharomyces cerevisiae and is a fungal probiotic.It can regulate the intestinal flora and enhance the barrier function of the intestinal tract.Compared with bacterial probiotics,Saccharomyces boulardii is more resistant to acid and oxidation,does not transmit genetic material with bacteria,and can be used in combination with antibiotics.Saccharomyces boulardii can function through a variety of mechanisms,and many proteases secreted by it have antitoxin effects;its own bacteria contain more polyamines,which can nourish the intestinal mucosal cells and regulate the body's metabolic balance.Besides,it can regulate multiple signal pathways to enhance intestinal immunity.Saccharomyces boulardii has been used in the treatment of ulcerative colitis(UC).The results of animal experiments and clinical studies have shown that the application of Saccharomyces boulardii can improve intestinal inflammation and enhance the therapeutic effect of mesalazine.Saccharomyces boulardii can be used as an auxiliary drug for the treatment of UC.

关 键 词：布拉氏酵母菌 生物学特性 作用机制 溃疡性结肠炎 肠道菌群 

分 类 号：R574.62[医药卫生—消化系统]