原发性乳腺弥散性大B细胞淋巴瘤临床病理分析  

Clinicopathologic analiysis of primary diffuse large B cell lymphoma of the breast

作　　者：汪静皎[1] 蔡颖[1] 杨树东[1] Wang Jingjiao;Cai Ying;Yang Shudong(The Wuxi People's Hospital Affiliated to Naning Medical University,Wuxi,Jiangsu 214023)

机构地区：[1]南京医科大学附属无锡市人民医院,江苏无锡214023

出　　处：《基层医学论坛》2021年第19期2687-2689,F0003,共4页The Medical Forum

摘　　要：目的探讨原发性乳腺弥散性大B细胞淋巴瘤的病理学形态、免疫表型特征与预后的关系。方法本组收录了5例原发性乳腺弥散性大B细胞淋巴瘤患者的资料,分析其临床病理及免疫表型特征,并随访其预后。结果5例乳腺原发性弥散性大B细胞淋巴瘤,4例为手术切除标本,1例为粗针活检标本,其组织学特征表现为瘤细胞呈弥散浸润性生长,瘤细胞体积大,核圆形或卵圆形,大而深染,部分瘤细胞内见小核仁;瘤细胞增殖活跃,核分裂象易见;其免疫组化表型均为非生发中心亚型。明确病理诊断,患者均进行化疗,目前1例死亡。结论乳腺原发性弥散性大B细胞淋巴瘤少见,空心针穿刺并辅以免疫组化可明确诊断。R-CHOP仍是最为有效的化疗方案。Objective To detect the pathological characteristics,immunophenotype and prognosis of primary diffuse large B cell lymphoma.Methods The clinicopathological and immunophenotypic features were reviewed in five cases of primary breast diffuse large B cell lymphoma.All cases was followed up.Results All cases displayed simillar characteristics microscopically,whether from lumpectomy or core needle biopsy tissues.The lesions were composed of diffused infilration of medium to large lymphoid tumor cells with round to oval nucleus,vesicular cnromatin and small nucleoli.Tumor cells proliferated actively and mitotic figures could be easily found.Immunohistochemical staining showed high Ki67 proliferative index in tumor cells and all five cases belonged to non-GCB subtype.Patients received chemotherapy and one died.Conclusion Primary breast diffuse large B cell lymphoma was rare.Combination of core needle biopsy and immunohistochemistry study are of great help to make diagnosis.R-CHOP remains to be the most effective treatment.

关 键 词：乳腺 弥散性大B细胞淋巴瘤 原发性 病理诊断 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]