血清TBA、CHE联合常规肝功能指标在不同肝病诊断中的临床价值  

The value of serum TBA,CHE and routine liver function indexes in clinical diagnosis of different liver diseases

作　　者：全首祯 李偌铱 梁佩 巩蓓 张谨 罗丹 高洁 董磊 马红雨 QUAN Shouzhen;LI Ruoyi;GONG Bei;LIANG Pei;ZHANG Jin;LUO Dan;GAO Jie;DONG Lei;MA Hongyu(Clinical Laboratory Department,Air Force Medical Center of PLA,Beijing 100142,China)

机构地区：[1]空军特色医学中心临床检验科,北京100142

出　　处：《国际检验医学杂志》2021年第S01期174-176,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨血清总胆汁酸(TBA)、胆碱酯酶(CHE)联合常规肝功能指标在不同肝病鉴别诊断中的应用价值。方法选取2017年1-5月在该院诊治的108例不同类型肝病患者作为肝病组,同时选取20例同期入院体检的体检健康者作为对照组,分析各组相关指标检测结果。结果与对照组比较,肝病组CHE、视黄醇结合蛋白(RBP)、前清蛋白(PA)水平均显著降低,差异有统计学意义(P<0.05),丙氨酸氨基转移酶(ALT)、TBA、天门冬氨酸氨基转移酶(AST)水平显著增高,差异有统计学意义(P<0.05);不同肝病类型患者CHE、RBP、PA、ALT、TBA、AST水平均存在显著差异,差异有统计学意义(P<0.05);不同肝病类型患者PA、RBP、CHE异常检出率差异均有统计学意义(P<0.05),TBA在不同类型肝病患者中均呈现较高阳性检出率,RBP及PA在肝炎组及肝硬化组中的阳性检出率较高,CHE在肝硬化组、肝癌组及重症肝炎组中均呈现较高的阳性检出率。结论TBA、CHE水平及常规肝功能指标均可较为敏感的反映肝脏功能及病变进展情况,多项指标联合检测有助于提高不同类型肝脏疾病的临床诊断准确性。Objective To evaluate the value of serum TBA,CHE combined with routine liver function indexes in clinical diagnosis of different liver diseases.Methods One hundred and eight patients with different types of liver diseases treated in our hospital from January to may 2017 were selected as the liver disease group,and 20 healthy people admitted for physical examination in the same period were selected as the control group.The detection results of relevant indicators in each group were analyzed.Results Compared with the control group,the levels of CHE,RBP and PA were significantly lower,and the levels of ALT,TBA and AST were significantly higher in the liver disease group(P<0.05).In different liver diseases,the levels of CHE,RBP,PA,ALT,TBA and AST were significantly different(P<0.05).The positive detection rates of PA,RBP and Che in patients with different liver diseases were significantly different(P<0.05).TBA showed a high positive detection rate in all liver disease types.The positive detection rates of RBP and PA were higher in hepatitis group and cirrhosis group.CHE had higher positive rate in liver cirrhosis group,liver cancer group and severe hepatitis Group.Conclusion The levels of TBA,CHE and routine liver function indexes could sensitively reflect the status of liver function and the occurrence of parenchymal diseases,and the combined detection of multiple indexes will be helpful to improve the accuracy of clinical diagnosis of different liver diseases.

关 键 词：肝病类型 诊断 总胆汁酸 胆碱酯酶 

分 类 号：R57[医药卫生—消化系统]