视神经脊髓炎谱系疾病患者副肿瘤特征性抗体筛查分析  

Analysis of well characterized onconeural antibodies screening in patients with neuromyelitis optica spectrum disorders

作　　者：邵春青[1] 张冬琬 吕虹[1] 马瑞敏[1] 王毅娟[1] 杨薇[1] 张国军[1] SHAO Chunqing;ZHANG Dongwan;LV Hong;MA Ruimin;WANG Yijuan;YANG Wei;ZHANG Guojun(Department of Clinical Laboratory,Beijing Tiantan Hospital,Capital Medical University/Beijing Engineering Research Center of Immunological Reagents Clinical Research,Beijing 100070,China;Faculty of Clinical Laboratory Diagnosis,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院检验科/北京市免疫试剂临床工程技术研究中心,北京100070 [2]首都医科大学临床检验诊断学系,北京100070

出　　处：《国际检验医学杂志》2021年第14期1757-1759,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨对视神经脊髓炎谱系疾病(NMOSD)患者进行副肿瘤特征性抗体常规筛查的必要性。方法回顾性分析71例NMOSD患者的临床及实验室资料,其中水通道蛋白-4(AQP4)-IgG阳性患者51例(71.8%),阴性或未能检测者20例(28.2%)。副肿瘤特征性抗体采用免疫印迹法检测。结果71例NMOSD患者中,4例(5.6%)检测出抗Amphiphysin抗体。1例(1.4%)不能排除肿瘤,31例(43.7%)存在肿瘤标志物异常。结论副肿瘤特征性抗体在NMOSD患者中虽然罕见,但筛查副肿瘤特征性抗体可以全面了解患者是否存在副肿瘤病因及免疫状态。Objective To investigate the necessity of routine screening for characterized onconeural antibodies in patients with neuromyelitis optica spectrum disorders(NMOSD).Methods The clinical and laboratory data of 71 patients with NMOSD were retrospectively analyzed.Among them,51(71.8%)were positive for Aquaporin-4(AQP4)-IgG,and 20(28.2%)were negative or undetectable.The characterized onconeural antibodies were detected by Western blotting.Results Anti-Amphiphysin antibody was detected in 4(5.6%)of 71 NMOSD patients.One case(1.4%)could not be excluded tumor and 31 cases(43.7%)had abnormal tumor markers.Conclusion Although characterized onconeural antibodies are rare in NMOSD patients,screening for these antibodies can fully understand the cause and immune status of NMOSD patients.

关 键 词：视神经脊髓炎谱系疾病 水通道蛋白-4 副肿瘤特征性抗体 副肿瘤性神经系统综合征 

分 类 号：R744.52[医药卫生—神经病学与精神病学]