miR-19b-3p、MnSOD、NO/ET-1与脑梗死后血管性痴呆预测效能  

Predictive efficacy of miR-19b-3p,MnSOD,NO/ET-1 on vascular dementia after cerebral infarction

作　　者：高华[1] 杨嘉君[1] 张新华 GAO Hua;YANG Jiajun;ZHANG Xinhua(Department of Neurology,Shanghai Sixth People's Hospital,Shanghai,China,201306;General Practice,Shanghai Sixth People's Hospital,Shanghai,China,201306)

机构地区：[1]上海市第六人民医院神经内科,上海201306 [2]上海市第六人民医院全科医学,上海201306

出　　处：《分子诊断与治疗杂志》2021年第6期865-868,872,共5页Journal of Molecular Diagnostics and Therapy

基　　金：上海市卫生和计划生育委员会中医药科研基金(2014LP007B)。

摘　　要：目的探讨微小RNA-19b-3p(miR-19b-3p)、锰超氧化物歧化酶(MnSOD)、一氧化氮与内皮素-1比值(NO/ET-1)对脑梗死后血管性痴呆(VaD)的预测效能。方法选取2017年5月至2020年6月本院收治的80例脑梗死患者,根据6个月内是否发生VaD分为VaD组(n=21)、无VaD组(n=57)。比较两组基线资料、治疗前和出院时miR-19b-3p、MnSOD、NO/ET-1、简易智力状态检查量表(MMSE)评分,采用Pearson及偏相关性分析miR-19b-3p、MnSOD、NO/ET-1与MMSE评分相关性,受试者工作特征曲线(ROC)分析miR-19b-3p、MnSOD、NO/ET-1预测VaD的价值。结果 80例脑梗死患者,随访6个月,失访2例,VaD发生率为26.92%(21/78);VaD组吸烟史、入院时NIHSS评分、糖尿病分布情况与无VaD组比较,差异有统计学意义(P<0.05);出院时VaD组miR-19b-3p高于无VaD组,MnSOD、NO/ET-1、MMSE评分低于无VaD组,差异有统计学意义(P<0.05);miR-19b-3p与MMSE呈负相关,MnSOD、NO/ET-1与MMSE评分呈正相关(P<0.05);将吸烟史、入院时NIHSS评分、糖尿病因素控制后,miR-19b-3p、MnSOD、NO/ET-1仍与MMSE评分相关(P<0.05);miR-19b-3p+MnSOD+NO/ET-1预测VaD的AUC为0.957,大于单一指标预测(P<0.05)。结论 miR-19b-3p、MnSOD、NO/ET-1可作为临床评估脑梗死后VaD发生风险的非侵入性指标,有助于临床早期识别、干预,以改善患者预后。Objective To investigate the predictive performance of microRNA-19b-3p(miR-19b-3p),manganese superoxide dismutase(MnSOD),nitric oxide/endothelin-1(NO/ET-1)on vascular dementia(VaD)after cerebral infarction. Methods From May 2017 to June 2020,80 patients with cerebral infarction in our hospital were selected and divided into the VaD group(n=21)and the non VaD group(n=57)according to whether VaD occurred within 6 months. The baseline data,miR-19b-3p,MnSOD,NO/ET-1,and Mini Mental State Examination Scale(MMSE)scores before treatment and at discharge were compared between the two groups. Pearson and partial correlation were used to analyze the correlation between miR-19 b-3 p,MnSOD,NO/ET-1 and MMSE score. Receiver operating characteristic curve(ROC)was used to analyze the value of miR-19b-3p,MnSOD,and NO/ET-1 in predicting VaD. Results Eighty patients with cerebral infarction were followed up for 6 months,and 2 cases were lost to follow-up. The incidence of VaD was 26.92%(21/78). The smoking history,NIHSS score at admission,and the distribution of diabetes in the VaD group were significantly different from those in the non VaD group(P<0.05). The miR-19b-3p in the VaD group was higher than that in the non Va D group at discharge,and the scores of Mn SOD,NO/ET-1 and MMSE were lower than those in the non Va D group(P<0.05). miR-19b-3p was negatively correlated with MMSE. MnSOD,and NO/ET-1 were positively correlated with MMSE score(P<0.05). After controlling for smoking history,NIHSS score at admission,and diabetes factors,miR-19b-3p,MnSOD,and NO/ET-1 were still correlated with MMSE score(P<0.05). The AUC of Va D predicted by mi R-19b-3p+Mn SOD+NO/ET-1 was 0.957,which was greater than that predicted by a single indicator(P<0.05). Conclusion mi R-19 b-3 p,Mn SOD,and NO/ET-1 can be used as non-invasive indicators for clinical evaluation of the risk of VaD after cerebral infarction,which is helpful for early clinical identification and intervention to improve the prognosis of patients.

关 键 词：微小RNA-19b-3p 锰超氧化物歧化酶 一氧化氮 内皮素-1 脑梗死 血管性痴呆 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R749.13[医药卫生—临床医学]