上皮性卵巢癌患者血清HMGA2、IL-22、FOLR1水平及与临床指标的相关性  

Serum HMGA2,IL-22,FOLR1 levels in patients with epithelial ovarian cancer and their correlation with clinical indicators

作　　者：陈睿琦 刘晓云 CHEN Ruiqi;LIU Xiaoyun(Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou,China,563000)

机构地区：[1]遵义医科大学第三附属医院妇产科,贵州遵义563000

出　　处：《分子诊断与治疗杂志》2021年第6期877-880,884,共5页Journal of Molecular Diagnostics and Therapy

基　　金：遵义市科学技术项目(2018JQ253)。

摘　　要：目的探究上皮性卵巢癌(EOC)患者血清高迁移率族蛋白A2(HMGA2)、白细胞介素-22(IL-22)、叶酸受体1(FOLR1)水平与临床指标的相关性。方法选取本院2018年10月至2020年9月收治的60例EOC患者作为EOC组,选择60例患者作为良性组,另选择同期健康体检者60例作为健康组,酶联免疫吸附试验检测各组研究对象血清HMGA2、IL-22、FOLR1水平,分析血清HMGA2、IL-22、FOLR1与EOC患者临床病理特征的关系,受试者工作特征曲线(ROC)分析HMGA2、IL-22、FOLR1诊断EOC的临床价值;根据研究期间患者复发情况分为复发组和未复发组,比较各组HMGA2、IL-22、FOLR1水平,Cox回归分析血清HMGA2、IL-22、FOLR1水平是否为影响EOC患者复发率的危险因素。结果3组血清HMGA2、IL-22、FOLR1水平比较结果:EOC患者>良性组>健康组,差异有统计学意义(P<0.05)。不同FIGO分期、组织分化程度、病理类型、有无淋巴结转移、腹水EOC患者血清HMGA2、FOLR1、IL-22水平比较,差异有统计学意义(P<0.05)。血清HMGA2、IL-22、FOLR1联合诊断具有更好的灵敏度(95%)、特异度(96.7%)。复发组EOC患者血清HMGA2、IL-22、FOLR1水平明显高于未复发组,差异有统计学意义(P<0.05),Cox回归分析显示HMGA2、IL-22、FOLR1异常升高是导致EOC患者复发的危险因素。结论血清HMGA2、IL-22、FOLR1水平异常升高与EOC发生发展、临床生物学行为及预后存在密切联系,可作为EOC诊断的有效指标。Objective To explore the correlation between serum high mobility group protein A2(HMGA2),interleukin-22(IL-22),folate receptor 1(FOLR1)and clinical indicators in patients with epithelial ovarian cancer(EOC). Methods Sixty EOC patients admitted to the Third Affiliated Hospital of Zunyi Medical University from October 2018 to September 2020 were selected as the EOC group,60 patients with benign ovarian tumors were selected as the benign group,and 60 patients with healthy physical examination during the same period were selected as the healthy group. The enzyme-linked immunosorbent assay was used to detect serum HMGA2,IL-22,and FOLR1 levels in each group of subjects,and analyze the relationship between serum HMGA2,IL-22,FOLR1 and clinicopathological characteristics of EOC patients,and the receiver operating characteristic curve(ROC)was drawn to analyze the clinical value of HMGA2,IL-22 and FOLR1 in the diagnosis of EOC. According to the death of patients during the study period,they were divided into death group and survival group. The levels of HMGA2,IL-22 and FOLR1 were compared between the two groups. Cox regression analysis was used to analyze whether serum HMGA2,IL-22 and FOLR1 levels were risk factors affecting the survival rate of EOC patients. Results The serum HMGA2,IL-22,and FOLR1 levels in EOC patients were significantly higher than those in the benign group and the healthy group,and the serum HMGA2,IL-22,and FOLR1 levels in the benign group were higher than those in the healthy group,the difference was statistically significant(P<0.05). Comparison of serum HMGA2,FOLR1,and IL-22 levels in patients with different FIGO stage,degree of tissue differentiation,pathological type,lymph node metastasis,ascites EOC patients,the difference was statistically significant(P<0.05). There were statistically significant differences of IL-22 among patients with different FIGO stage,degree of tissue differentiation,lymph node metastasis,and EOC ascites(P<0.05). The serum HMGA2,IL-22,FOLR1,combined diagnosis has better sens

关 键 词：上皮性卵巢癌 高迁移率族蛋白A2 白细胞介素-22 叶酸受体1 

分 类 号：R737.31[医药卫生—肿瘤]