卵巢上皮性癌中VEGF、CD4^(+)、CD8^(+)及COX-2表达与TIDC相关性  

Correlation between the expression of VEGF,CD4^(+),CD8^(+) and COX-2 in epithelial ovarian cancer and tumor infiltrating dendritic cells

作　　者：吴明燕 康雪芳 林月丽[1] 林也容 张兰[1] 黄丽玲 陈慧 WU Mingyan;KANG Xuefang;LIN Yueli;LIN Yerong;ZHANG Lan;HUANG Liling;CHEN Hui(Department of Obstetrics and Gynecology,No.909 Hospital of PLA Joint Logistics Support Force,Zhangzhou,Fujian,China,363000)

机构地区：[1]中国人民解放军联勤保障部队第九○九医院妇产科,福建漳州363000

出　　处：《分子诊断与治疗杂志》2021年第6期969-972,976,共5页Journal of Molecular Diagnostics and Therapy

基　　金：福建省科技厅计划项目(2016Y3125)。

摘　　要：目的分析卵巢上皮性癌中血管内皮生长因子(VEGF)、CD4^(+)、CD8^(+)及环氧合酶-2(COX-2)的表达与肿瘤浸润性树突状细胞(TIDC)的相关性。方法选取本院2016年12月至2020年1月收治的110例卵巢上皮性癌患者作为研究组,另选取同期进行体检的70例健康女性作为对照组。比较两组S-100及VEGF、COX-2、CD4^(+)、CD8^(+)表达情况。分析上述因子与卵巢上皮性癌病理特征及TIDC的相关性。结果研究组S-100、VEGF及COX-2阳性表达率和CD4^(+)、CD8^(+)水平均显著高于对照组,差异有统计学意义(P<0.05)。TIDC数密度与患者临床分期、腹水呈显著相关性(P<0.05)。VEGF、COX-2阳性表达率与患者临床分期及病理分级呈显著相关性(P<0.05)。浆液性癌患者CD4^(+)水平显著高于黏液性癌患者,差异有统计学意义(P<0.05)。CD8^(+)水平与患者临床分期、腹水及病理分级均呈显著相关性(P<0.05)。相关性分析结果显示,VEGF、COX-2、CD8^(+)与TIDC均呈负相关关系(P<0.05),CD4^(+)与TIDC无显著相关性(P>0.05)。结论卵巢上皮性癌组织中VEGF、COX-2、CD8^(+)、CD4^(+)均存在异常表达,且VEGF、COX-2、CD8^(+)水平可影响卵巢上皮性癌中TIDC的密度,可能影响宿主的抗肿瘤免疫能力与肿瘤的浸润转移。Objective To analyze the correlation between the expression of Vascular endothelial growth factor(VEGF),CD4,CD8 and Cyclooxygenase-2(COX-2)in patients with ovarian epithelial carcinoma and tumor infiltrating dendritic cells(TIDC). Methods 110 patients with epithelial ovarian cancer admitted to this hospital from December 2016 to January 2020 were selected as the study group. 70 healthy women who had physical examination during the same period were selected as the control group. The expressions of S-100 and VEGF,COX-2,CD4^(+)and CD8^(+)were compared between the two groups. The correlations between the above factors,the pathological characteristics of epithelial ovarian cancer and TIDC were analyzed. Results The positive expression rates of S-100,VEGF and COX-2,and the levels of CD4^(+)and CD8^(+)in the study group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05). TIDC number density was significantly correlated with the clinical stage and ascites of patients(P<0.05). The positive expression rates of VEGF and COX-2 were significantly correlated with the clinical stage and pathological grade of patients(P<0.05). The CD4^(+)level of patients with serous cancer was significantly higher than that of patients with mucinous cancer,and the difference was statistically significant(P<0.05). The CD8^(+)level was significantly correlated with the clinical stage,ascites,and pathological grade of the patients(P<0.05). The correlation analysis showed that VEGF,COX-2,and CD8^(+)were all negatively correlated with TIDC(P<0.05),and CD4^(+)had no significant correlation with TIDC(P<0.05). Conclusion There are abnormal expressions of VEGF,COX-2,CD8^(+),and CD4^(+)in ovarian epithelial cancer tissues,and the levels of VEGF,COX-2 and CD8^(+)can affect the density of TIDC in patients with epithelial ovarian cancer,which may affect the host’s anti-tumor immunity and invasive metastasis of tumor.

关 键 词：卵巢上皮性癌 肿瘤浸润性树突状细胞 环氧合酶-2 血管内皮生长因子 淋巴细胞 

分 类 号：R737.31[医药卫生—肿瘤]