VEGF、BCRP蛋白及血清LDH与晚期NSCLC一线化疗预后的关系  

Relationship between the levels of VEGF,BCRP,serum LDH and the prognosis of advanced non-small cell lung cancer first-line chemotherapy

作　　者：孔佑虔 王小玉 宋爱英[2] 唐寅[2] KONG Youqian;WANG Xiaoyu;SONG Aiying;TANG Yin(Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang,China,150040;Department of Oncology,First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang,China,150040)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院肿瘤科,黑龙江哈尔滨150040

出　　处：《分子诊断与治疗杂志》2021年第6期994-997,1001,共5页Journal of Molecular Diagnostics and Therapy

基　　金：黑龙江省中医药管理局2020年度科技计划项目(ZHY2020-105)。

摘　　要：目的分析VEGF及BCRP蛋白及血清LDH与晚期NSCLC一线化疗预后的关系。方法选取本院2016年6月至2018年6月间收治的115例晚期NSCLC患者,收集肿瘤组织及肿瘤旁的正常胃粘膜组织,分别作为癌组织组和癌旁正常组织组。比较VEGF及BCRP蛋白及血清LDH表达情况;统计患者化疗预后;采用多元Logistic回归分析影响晚期NSCLC患者化疗预后生存的危险因素;采用ROC分析VEGF及BCRP蛋白及血清LDH对晚期NSCLC患者化疗预后生存的预测价值。结果癌组织组VEGF、BCRP阳性表达率和血清LDH水平显著高于癌旁正常组织组,差异均有统计学意义(P<0.05)。经两年随访显示,患者2年生存率为31.30%(36/115)。组织中低分化、TNM分期:Ⅲ+Ⅳ期、淋巴转移、血清LDH异常升高、VEGF及BCRP蛋白阳性表达为影响晚期NSCLC患者化疗预后生存的独立危险因素(P<0.05)。ROC曲线显示:LDH、VEGF及BCRP及三者联合曲线下面积以联合检测最大(0.892)。结论VEGF及BCRP蛋白及血清LDH与晚期NSCLC患者化疗及预后密切相关,临床可根据该水平变化制定个体化治疗方案,对延长患者生存期具有重要作用。Objective To analyze the relationship between the levels of VEGF,BCRP,serum LDH and the prognosis of patients with advanced non-small cell lung cancer(NSCLC)after first-line chemotherapy. Methods 115 patients with advanced NSCLC admitted to this hospital from June 2016 to June 2018 were selected. The tumor tissue and the normal gastric mucosa tissue adjacent to the tumor were collected as the cancer tissue group and the normal tissue adjacent to the cancer group. The levels of serum LDH,VEGF and BCRP protein were measured and compared. The prognosis after first-line chemotherapy in patients with advanced NSCLC was counted. Multivariate logistic regression analysis was used to analyze the risk factors that affect the prognosis survival of patients with advanced NSCLC after chemotherapy. ROC was used to analyze the predictive value of VEGF,BCRP protein and serum LDH for the prognostic survival of patients with advanced NSCLC after chemotherapy. Results The positive expression rates of VEGF and BCRP and serum LDH level in the cancer tissue group were significantly higher than those in the adjacent normal tissue group,and the differences were statistically significant(P<0.05). The patients were followed up for two years,and the 2-year survival rate of the patients was 31.30%(36/115). Multivariate logistic regression showed that the poor differentiation in tissues,TNM stage:Ⅲ+Ⅳ stage,lymphatic metastasis,abnormal increase in serum LDH,positive expression of VEGF and BCRP protein were independent risk factors affecting the prognosis survival of patients with advanced NSCLC after first-line chemotherapy(P<0.05). The ROC curve showed that the area under the curve of LDH,VEGF,BCRP and the area under the curve of combined test was the largest(0.892). Conclusion VEGF,BCRP protein and serum LDH are closely related to chemotherapy and prognosis in patients with advanced NSCLC. Clinically,individualized treatment plans can be formulated based on changes in this level,which plays an important role in prolonging the survival

关 键 词：血清LDH VEGF蛋白 BCRP蛋白 晚期非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]