mGluRs调节皮层-纹状体突触可塑性与运动防治帕金森病的研究进展  

mGluRs-mediated plasticity of corticostriatal pathway and the progress on exercise prevention of Parkinson’s disease

作　　者：时凯旋 牟彬 曾卫 侯莉娟[2] SHI Kai-Xuan;MOU Bin;ZENG Wei;HOU Li-Juan(College of P.E and Sports,Beijing Normal University,Beijing 100875,China;Department of Physical Education,China University of Geosciences,Beijing 100083,China)

机构地区：[1]中国地质大学(北京)体育部,北京100083 [2]北京师范大学体育与运动学院,北京100875

出　　处：《生命科学》2021年第5期605-610,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(32000833);中央高校基本科研项目(2652018282)。

摘　　要：皮层-纹状体谷氨酸(glutamate, Glu)能通路的异常兴奋是帕金森病(Parkinson’s disease, PD)的关键病理基础。代谢性谷氨酸受体(metabotropic glutamate receptors, mGluRs)可通过调节突触前Glu释放和突触后传递调控皮层-纹状体突触可塑性,是PD临床治疗的重要干预靶点。运动疗法作为PD康复的重要手段,可显著减缓PD运动和认知的退变,其机制可能与重塑皮层-纹状体突触结构与功能有关。该文就mGluRs调控皮层-纹状体通路Glu传导与运动防治PD的神经生物学机制等方面进行综述。Hyperexcitability in the corticostriatal glutamatergic pathway may play a pivotal role in the pathogenesis of Parkinson’s disease(PD). Metabotropic glutamate receptors(m Glu Rs) modulate glutamate transmission by both pre-and postsynaptic mechanisms, making them attractive targets for modifying pathological changes in the corticostriatal pathway. Exercise reportedly alleviates motor and cognitive dysfunction via inducing neuroplasticity in corticostriatal synaptic junction. Here, the m Glu R-mediated glutamatergic transmission in corticostriatal pathway and the plasticity mechanism underlying behavioral improvement by exercise intervention was reviewed.

关 键 词：帕金森病 运动 代谢性谷氨酸受体 皮层-纹状体通路 谷氨酸 

分 类 号：R742.5[医药卫生—神经病学与精神病学]