Moracin M的简便合成及其生物活性  

Concise Synthesis and Biological Activities of Moracin M

作　　者：李敏欣 杜文绒 高金春 李磊 李艳平 毛泽伟 LI Min-xin;DU Wen-rong;GAO Jin-chun;LI Lei;LI Yan-ping;MAO Ze-wei(College of Pharmaceutical Science,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学中药学院,云南昆明650500

出　　处：《合成化学》2021年第7期624-627,共4页Chinese Journal of Synthetic Chemistry

基　　金：云南省科学技术厅-云南中医药大学应用基础研究联合专项(202001AZ070001-007,202001AZ070001-038);云南中医药大学大学生创新创业训练计划项目(2019066)。

摘　　要：以4-甲氧基水杨醛和3,5-二甲氧基溴化苄为原料,经取代、缩合和水解等3步反应,以38%的总收率合成了Moracin M。分别采用DPPH自由基清除法、小鼠巨噬细胞RAW264.7模型初步测试了Moracin M的抗氧化活性和体外抗炎活性,结果表明该化合物对DPPH自由基的清除能力很强(IC_(50)=0.0433 mg/mL),优于阳性对照药V C,且具有一定的抗炎活性。In this study,concise synthesis of Moracin M has been achieved by three steps from 4-methoxysalicylaldehyde and 3,5-dimethoxybenzyl bromide with 38%total yield.In addition,the antioxidant activity of Moracin M was evaluated by DPPH free radical scavenging assay,and the in vitro anti-inflammatory activity of Moracin M was tested by using the murine macrophage RAW264.7 model.The result demonstrated that it showed good scavenging ability against DPPH free radical(IC_(50)=0.0433 mg/mL),which was better than that of V C,and had a certain anti-inflammatory activity.

关 键 词：Moracin M 合成 抗氧化活性 抗炎活性 4-甲氧基水杨醛 3 5-二甲氧基溴化苄 

分 类 号：O625[理学—有机化学] O657[理学—化学]