Endocannabinoids regulate fear memory generalization via hippocampal local circuits  

作　　者：Ge Qian Han Jing 

机构地区：[1]Institute of Neurobiology,Xi'an Jiaotong University,Xi'an 710061,China [2]Key Laboratory of Modern Teaching Technology,Shaanxri Normal University

出　　处：《解剖学杂志》2021年第S01期83-83,共1页Chinese Journal of Anatomy

摘　　要：Generalization is widely accepted as adaptive behavioral conditions that allow individuals to quickly respond to similar circumstances.But once overgeneralization occurs,e.g.due to the inability to suppress generalized fear,it could result in anxiety,depression and related mental disorders.Endocannabinoids(eCB)are important endogenous substance,known to play a role in contextual fear memory generalization.However,less is known in terms of the precise neural mechanism and the regulation of overgeneralization,in particular,for the eCB/CB1R signaling.Using fear memory generalization task,we show that type 1 cannabinoid receptors(CB1R)in hippocampal GABAergic neurons are necessary and sufficient for avoiding overgeneralization.Suppression or deletion of CB1R in hippocampal GABAergic neurons produces overgeneralized contextual fear memory.

关 键 词：GENERALIZATION ENDOGENOUS PRECISE 

分 类 号：R74[医药卫生—神经病学与精神病学]