BDNF secreted from nerve fibroblasts promotes neurite outgrowth of motoneurons by activating ERK and AKT pathway  

作　　者：He Qianru Shi Haiyan Cong Meng Ding Fei 

机构地区：[1]Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education,Nantong University,Nantong 226000

出　　处：《解剖学杂志》2021年第S01期97-98,共2页Chinese Journal of Anatomy

摘　　要：Peripheral nerve fibroblasts play an important role in the process of nerve development and regeneration.The present study revealed that fibroblasts with different tissue sources,such as peripheral nerve fibroblasts(N-Fbs)and cardiac Fbs(C-Fbs),exerted distinct effects on motoneurons.Compared to C-Fbs,N-Fbs significantly promoted neurite outgrowth of motoneurons in vitro.mRNA sequencing identified a total of 491 differentially expressed genes between N-Fbs and C-Fbs.Out of them,130 genes were significantly upregulated in N-Fbs than in C-Fbs,and these genes might be involved in axon guidance and neuron projection.

关 键 词：MOTONEURON cardiac AKT 

分 类 号：R31[医药卫生—基础医学]