MOTONEURON

作品数：19被引量：29H指数：4
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相关领域：医药卫生更多>>
相关作者：陈新华赵立杰李笑男更多>>
相关机构：长春中医药大学附属医院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Chinese Medical Journal》《Neural Regeneration Research》《Science Bulletin》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Downregulation of EphB2 by RNA interference attenuates glial/fibrotic scar formation and promotes axon growth被引量：4
《Neural Regeneration Research》2022年第2期362-369,共8页Jian Wu Zhen-Yu Zhu Zhi-Wei Fan Ying Chen Ri-Yun Yang Yi Li 
supported by the Priority Academic Program Development of Jiangsu Higher Education Institutes of China(PAPD);the Science and Technology Plan Project of Nantong of China,No.JC2020026(to JW);the National Science Research of Jiangsu Higher Education Institutions of China,No.19KJB310012(to RYY)。
The rapid formation of a glial/fibrotic scar is one of the main factors hampering axon growth after spinal cord injury. The bidirectional Eph B2/ephrin-B2 signaling of the fibroblast-astrocyte contact-dependent intera...
关键词：ASTROCYTE EPHB2 FIBROBLAST glial/fibrotic scar microfluidic platform RNAi spinal cord injury VSC4.1 motoneuron 
BDNF secreted from nerve fibroblasts promotes neurite outgrowth of motoneurons by activating ERK and AKT pathway
《解剖学杂志》2021年第S01期97-98,共2页He Qianru Shi Haiyan Cong Meng Ding Fei 
Peripheral nerve fibroblasts play an important role in the process of nerve development and regeneration.The present study revealed that fibroblasts with different tissue sources,such as peripheral nerve fibroblasts(N...
关键词：MOTONEURON cardiac AKT 
Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries被引量：4
《Neural Regeneration Research》2020年第9期1639-1649,共11页Yanjun Xie Kevin J.Schneider Syed A.Ali Norman D.Hogikyan Eva L.Feldman Michael J.Brenner 
supported by the United States National Institute of Health grant 1K08DC012535(to MJB);Program for Neurology Research and Discovery;the Sinai Medical Staff Foundation Neuroscience Scholar Fund(to ELF)
The intricate anatomy and physiology of cranial nerves have inspired clinicians and scientists to study their roles in the nervous system. Damage to motor cranial nerves may result from a variety of organic or iatroge...
关键词：axon degeneration cranial neuropathy facial nerve facial paralysis MOTONEURON nerve regeneration peripheral nerve recurrent laryngeal nerve SYNKINESIS vocal fold paralysis 
Exercise promotes recovery after motoneuron injury via hormonal mechanisms被引量：1
《Neural Regeneration Research》2020年第8期1373-1376,共4页Cory Chew Dale R.Sengelaub 
supported by NIH-NINDS NS047264 to DRS
Injuries to spinal motoneurons manifest in a variety of forms,including damage to peripheral axons,neurodegenerative disease,or direct insult centrally.Such injuries produce a variety of negative structural and functi...
关键词：axon regeneration AXOTOMY dendritic morphology EXERCISE HORMONES neuroprotection NEUROTROPHINS 
Network-centric medicine for peripheral nerve injury:treating the whole to boost endogenous mechanisms of neuroprotection and regeneration被引量：2
《Neural Regeneration Research》2019年第7期1122-1128,共7页David Romeo-Guitart Caty Casas 
mainly supported by the Ministerio de Economíay Competitividad of Spain(#SAF 2014-59701)(to CC)
Peripheral nerve injuries caused by accidents may lead to paralysis,sensory disturbances,anaesthesia,and lack of autonomic functions.Functional recovery after disconnection of the motoneuronal soma from target tissue ...
关键词：MOTONEURON NEURODEGENERATION AXONAL REGENERATION muscle ATROPHY systems biology neuroheal PI3K/AKT SIRTUIN 1 motor function recovery 
Neural computational modeling reveals a major role of corticospinal gating of central oscillations in the generation of essential tremor被引量：2
《Neural Regeneration Research》2017年第12期2035-2044,共10页Hong-en Qu Chuanxin M.Niu Si Li Man-zhao Hao Zi-xiang Hu Qing Xie Ning Lan 
supported in part by the National Natural Science Foundation of China,No.61361160415,81271684,81501570;the Major State Basic Research Development of China(973 Program),No.2011CB013304;the Medicine-Engineering Interdisciplinary Research Grant from Shanghai Jiao Tong University in China,No.YG2014ZD09;a grant from the Youth Eastern Scholar Program at Shanghai Institutions of Higher Learning in China,No.QD2015007
Essential tremor, also referred to as familial tremor, is an autosomal dominant genetic disease and the most common movement disorder. It typically involves a postural and motor tremor of the hands, head or other part...
关键词：nerve regeneration NEURODEGENERATION essential tremor propriospinal neurons MOTONEURON REFLEX modeling motor control oscillation neurological disorder movement disorder computational neuroscience neural regeneration 
Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis被引量：3
《Neural Regeneration Research》2017年第10期1664-1679,共16页Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller Kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders Kathryn J.Jones 
supported by a grant from National Institute of Health(NIH);Grant No.NS040433
Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival.Early identification and enhanced understanding of symptomatic ...
关键词：nerve regeneration amyotrophic lateral sclerosis motoneuron degenerative disease locomotor disease progression disease variability SOD1 mouse neural regeneration 
F Wave Study in Amyotrophic Lateral Sclerosis： Assessmen of Segmental Motoneuronal Dysfunction被引量：5
《Chinese Medical Journal》2015年第13期1738-1742,共5页Jia Fang Li-Ying Cui Ming-Sheng Liu Yu-Zhou Guan Xiao-Guang Li Bo Cui Qing-Yun Ding 
Background： Dysfunctional spinal circuit may play a role in the pathophysiology ofarnyotrophic lateral sclerosis （ALS）. The purpose of this study was to use F waves for assessment of segmental motoneuronal excitabi...
关键词：Amyotrophic Lateral Sclerosis： Excitability F wave Segmental Motoneuron Upper Motor Neuron 
Spinal root avulsion:an excellent model for studying motoneuron degeneration and regeneration after severe axonal injury被引量：1
《Neural Regeneration Research》2014年第2期117-118,共2页Carolin Ruven Tak-Kwong Chan Wutian Wu 
Spinal root avulsion is an excellent model for studying the re- sponse of motoneurons to severe injury to their axons （Koliat- sos et al., 1994）. In this model （‘Avulsion Model＇）, spinal roots are torn off from ...
关键词：root GDNF Spinal root avulsion 
P75 and phosphorylated c-Jun are differentially regulated in spinal motoneurons following axotomy in rats
《Neural Regeneration Research》2012年第26期2005-2011,共7页Qiuju Yuan Huanxing Su Wutian Wu Zhi-Xiu Lin 
supported by Direct Grant (Project No.2030392) of the Chinese University of Hong Kong;HK Spinal Cord Injury Foundation;National Key Basic Research Support Foundation (973 Project: 2011CB504402)
The neurotrophin receptor （p75） activates the c-Jun N-terminal kinase （JNK） pathway. Activation of JNK and its substrate c-Jun can cause apoptosis. Here we evaluate the role of p75 in spinal motoneurons by compari...
关键词：apoptosis transcription factor c-Jun N-terminal kinase nerve growth factor receptor MOTONEURON spinal cord AXOTOMY NEONATAL adult axonal regeneration 
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