Tanshinone IA decreases microcalcifications in plaque via Nox1-dependent reactive oxygen species generation of smooth muscle cells in apoE^(-/-) mice  

作　　者：Sun Weiliang Guo Jing Zhang Yuting Gao Yanxiang 

机构地区：[1]Institute of Clinical Medical Sciences,China Japan Friendship Hospital,Beijing 100029,China [2]Department of Cardiology,China-Japan Friendship Hospital

出　　处：《解剖学杂志》2021年第S01期165-166,共2页Chinese Journal of Anatomy

摘　　要：A variety of NADPH oxidase(Nox)isoforms including Noxs 1,2,4 and 5 catalyze the formation of reactive oxygen species(ROS)in the vascular wall.The Noxl isoform complex in smooth muscle cells has received greater attention in the progression of atherogenesis in animal models.Thus,we explored the effect of traditional Chinese herbal medicine monomer tanshinone IIA on microcalcifications,and investigated the underlying molecular mechanism of ROS.The 8-week old maleapolipoprotein E-deficient(ApoE^(-/-))mice and C57BL/6 mice were divided into three groups:Control group(C57BL/6 mice),Model group(ApoE^(-/-) mice).

关 键 词：C57BL/6 herbal reactive 

分 类 号：R74[医药卫生—神经病学与精神病学]