音乐运动治疗对轻度阿尔茨海默病患者记忆、精神症状和日常生活能力的作用  

Effects of physical exercise combined with music on memory,psychological symptoms and activities of daily living in patients with mild Alzheimer′s disease

作　　者：母海艳[1] 吕继辉[1] 崔梦楠 郝智慧[1] 李文杰[1] 李沫[1] MU Hai-Yan;LYU Ji-Hui;CUI Meng-Nan;HAO Zhi-Hui;LI Wen-Jie;LI Mo(Second Department of Psychiatry and Psychology,Beijing Geriatric Hospital,Beijing 100095,China)

机构地区：[1]北京老年医院精神心理二科,北京100095

出　　处：《中华老年多器官疾病杂志》2021年第7期514-517,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的评价音乐运动治疗对轻度阿尔茨海默病患者记忆、精神症状和日常生活能力的作用。方法选择2016年12月至2018年5月就诊于北京老年医院患者89例,按照随机数表法随机将患者分为音乐运动组(31例)、运动治疗组(30例)和对照组(28例)。音乐运动组患者在音乐伴奏下进行体育运动,运动治疗组患者进行相同的运动但无音乐伴奏,均累计每周≥3次,运动时间≥200 min,持续3个月。对照组患者按常规诊疗无特殊干预。所有受试者在干预前和干预后3个月接受相关神经心理学测验。采用SPSS 13.0软件进行数据分析。根据数据类型,组间比较分别采用χ^(2)检验、t检验或者方差分析。结果干预后3个月,音乐运动组和对照组MMSE评分比较,差异有统计学意义[(18.90±1.92)和(17.60±2.10)分,P<0.05];音乐运动组NPI评分较治疗前下降[(16.03±5.61)和(19.19±5.25)分,P<0.05],运动治疗组治疗后NPI评分较治疗前下降[(15.80±5.38)和(18.90±6.47)分],差异均有统计学意义(均P<0.05);音乐运动组照料者苦恼程度评分较治疗前改善[(17.16±5.37)和(20.90±6.48)分],运动治疗组治疗后照料者苦恼程度评分较治疗前改善[(19.30±7.20)和(21.93±6.77)分],差异均有统计学意义(均P<0.05);对照组治疗后ADL评分较治疗前下降,差异有统计学意义[(81.07±6.29)和(85.31±6.37)分,P<0.05];3组患者治疗前后及组间词语流畅性测试比较,差异均无统计学意义(均P>0.05)。结论音乐运动疗法能够改善患者的记忆和精神症状,但较单独运动组未显示出明显优势。Objective To explore the effects of physical exercise combined with music on memory,psychological symptoms,and activities of daily living(ADL)in patients with mild Alzheimer′s disease(AD).Methods Eighty-nine patients with mild AD admitted to our hospital from December 2016 to May 2018 were randomly divided into physical exercise combined with music group(musicokinetic therapy group,n=31),physical exercise without music accompaniment group(physical therapy group,n=30)and control group(n=28).Similar physical exercise were performed in the former 2 groups with music accompaniment or not,at≥3 times per week,for≥200 min per time,totally 3 consecutive months.The patients from the control group received no special interventions according to routine diagnosis and treatment.All subjects were given neuropsychological tests before and in 3 months after the interventions.SPSS statistics 13.0 was used to perform the statistical analysis.Student′s t test,Chi-square test,or analysis of variance was employed for intergroup comparison depending on different data types.Results In 3 months after intervention,the musicokinetic therapy group obtained significantly higher mini-mental state examination(MMSE)score when compared with the control group[(18.90±1.92)vs(17.60±2.10)points,P<0.05].And the score of neuropsychiatric inventory(NPI)was decreased from(19.19±5.25)to(16.03±5.61)points in the musicokinetic therapy group(P<0.05),and from(18.90±6.47)to(15.80±5.38)points in the physical therapy group(P<0.05).The distress score of caregivers was also greatly improved in above 2 groups[from(20.90±6.48)to(17.16±5.37)points and from(21.93±6.77)to(19.30±7.20)points,respectively;both P<0.05].The ADL score was decreased in the control group after treatment[(81.07±6.29)vs(85.31±6.37)points,P<0.05].There were no significant difference in the results of Auditory Verbal Learning Test among the 3 groups before and after treatment(all P>0.05).Conclusion Musicokinetic therapy can improve the memory and mental symptoms of mild AD pa

关 键 词：阿尔茨海默病 音乐运动治疗 记忆 精神症状 日常生活能力 

分 类 号：R749.16[医药卫生—神经病学与精神病学]