Koenigs-Knorr糖基化反应的研究进展  

Research progress of Koenigs-Knorr glycosylation

作　　者：田思思 TIAN Si-si(School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津大学药物科学与技术学院,天津300072

出　　处：《化学工程师》2021年第6期56-60,45,共6页Chemical Engineer

摘　　要：糖苷化合物广泛存在于药物分子和天然产物中,且具有重要的生物活性。Koenigs-Knorr糖基化反应作为构筑糖苷键的经典反应,被广泛应用于糖苷化合物的合成,已成为当今糖化学领域的一个研究热点。本文简单介绍Koenigs-Knorr糖基化反应及其特点,重点介绍近年来发展的一系列Koenigs-Knorr糖基化反应进展。Glycosides are widely found in natural products and drug molecules,which show significant biological activities.Koenigs-Knorr glycosylation is a classic reaction for glycosidic bond construction,which is widely used in the synthesis of glycoside compounds.Koenigs-Knorr glycosylation has become a research hotspot in the field of sugar chemistry today.This article briefly introduces the Koenigs-Knorr glycosylation reaction and its characteristics,and focuses on the development of a series of Koenigs-Knorr glycosylation reactions developed in recent years.

关 键 词：Koenigs-Knorr糖基化 糖苷化合物 立体选择性 

分 类 号：R914.5[医药卫生—药物化学]