Long- versus short-interval follow-up after resection of hepatocellular carcinoma: a retrospective cohort study  

作　　者：Wei He Yun Zheng Ruhai Zou Jingxian Shen Junping Yang Jiliang Qiu Qiang Tao Wenwu Liu Zhiwen Yang Yuanping Zhang Binkui Li Yunfei Yuan 

机构地区：[1]State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Sun Yat-Sen University Cancer Center,651 Dongfeng Road East,Guangzhou 510060,China [2]Department of Hepatobiliary Oncology,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China [3]Department of Ultrasound,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China [4]Department of Medical Imaging,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China

出　　处：《Cancer Communications》2018年第1期280-290,共11页癌症通讯（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.81372571 and 81772598);the Sun Yat-sen University Clinical Research 5010 Program(No.2012010);the State“973 Program”of China(2014CB542005);the Fundamental Research Funds for the Central Universities(17ykzd34).

摘　　要：Background:Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma(HCC)resection because of limited evidence regarding the optimal interval.We aimed to compare the associations of long-versus short-interval follow-up with survival and recurrence in risk-stratified HCC patients.Methods:We performed a retrospective cohort study between 2007 and 2014.In total,1227 patients treated by curative resection of Barcelona Clinic Liver Cancer stage A or B HCC were stratified as having a low(n=865)or high(n=362)risk of early recurrence(within the first 2 years after resection)based on prognostic factors identified by the least absolute shrinkage and selection operation algorithm.Patients were further classified into long-interval(every 4-6 months)and short-interval(every 2-4 months)follow-up subgroups based on follow-up within 2 years after resection(low risk,long vs.short:n=390 vs.n=475;high-risk,long vs.short:n=149 vs.n=213).Results:The short-interval follow-up did not prolong overall survival in either the low-risk(hazard ratio[HR]=1.152;95%confidence interval[CI]0.720-1.843)or high-risk(HR=1.213;95%CI 0.702-2.094)patients.Early recurrence occurred in 401 patients.For high-risk patients,the short-interval follow-up subgroup exhibited smaller intrahepatic recurrence than did the long-interval group(2.6 vs.3.5 cm,respectively,P=0.045).However,no significant difference in the rate of Barcelona Clinic Liver Cancer stage 0/A recurrence was found between the long-and short-interval follow-up groups in either low-or high-risk patients(63.1%vs.68.2%,respectively,P=0.580;31.3%vs.41.5%,respec-tively,P=0.280).The rate of curative intent treatment for recurrence(34.5%vs.39.7%,respectively,P=0.430;14.6%vs.20.3%,respectively,P=0.388)was also similar between the follow-up groups for low-and high-risk patients.Conclusions:Shortening the postoperative follow-up interval from every 4-6 months to every 2-4 months within the first 2 years after resection did not increase the rate of curative intent trea

关 键 词：Hepatocellular carcinoma HEPATECTOMY Prognosis SURVEILLANCE RECURRENCE 

分 类 号：R73[医药卫生—肿瘤]