When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance  

作　　者：Ching-Ying Kuo David K.Ann 

机构地区：[1]Department of Clinical Laboratory Sciences and Medical Biotechnology,College of Medicine,National Taiwan University,Taipei 10048,Taiwan,China [2]Department of Diabetes Complications and Metabolism,Diabetes and Metabolism Research Institute,Beckman Research Institute,City of Hope,Duarte,CA 91010,USA [3]Irell and Manella Graduate School of Biological Sciences,City of Hope,Duarte,CA 91010,USA

出　　处：《Cancer Communications》2018年第1期499-510,共12页癌症通讯（英文）

基　　金：supported in part by funds from the National Institutes of Health R01DE026304 and R01CA220693(to D.K.A.);Ministry of Science and Technology,R.O.C,Special Talents Award(to C.-Y.K).

摘　　要：The role of fatty acid metabolism,including both anabolic and catabolic reactions in cancer has gained increas-ing attention in recent years.Many studies have shown that aberrant expression of the genes involved in fatty acid synthesis or fatty acid oxidation correlate with malignant phenotypes including metastasis,therapeutic resistance and relapse.Such phenotypes are also strongly associated with the presence of a small percentage of unique cells among the total tumor cell population.This distinct group of cells may have the ability to self-renew and propagate or may be able to develop resistance to cancer therapies independent of genetic alterations.Therefore,these cells are referred to as cancer stem cells/tumor-initiating cells/drug-tolerant persisters,which are often refractory to cancer treatment and difficult to target.Moreover,interconversion between cancer cells and cancer stem cells/tumor-initiating cells/drug-tolerant persisters may occur and makes treatment even more challenging.This review highlights recent findings on the relationship between fatty acid metabolism,cancer stemness and therapeutic resistance and prompts discussion about the potential mechanisms by which fatty acid metabolism regulates the fate of cancer cells and therapeutic resistance.

关 键 词：Fatty acid synthesis Fatty acid oxidation Fatty acid metabolism Lipogenic phenotype Cancer stem cells Tumor-initiating cells Cancer cell plasticity Therapeutic resistance Drug-tolerant persisters 

分 类 号：R73[医药卫生—肿瘤]